https://www.selleckchem.com/products/jte-013.html And the abundance of Akkermansia, a critical probiotics, was markedly inhibited by the treatment of fluorine. In conclusion, the results suggested fluorine exposure changed the gut microbiome composition and led to the damage of intestinal structural integrity. With the advance of subthalamic nucleus (STN) deep brain stimulation (DBS) in the treatment of Parkinson's disease (PD), it is desired to identify objective criteria for the monitoring of the therapy outcome. This paper explores the feasibility of metabolic network derived from positron emission tomography (PET) with F-fluorodeoxyglucose in monitoring the STN DBS treatment for PD. Age-matched 33 PD patients, 33 healthy controls (HCs), 9 PD patients with bilateral DBS surgery and 9 controls underwent F-FDG PET scans. The DBS patients were followed longitudinally to investigate the alternations of the PD-related metabolic covariance pattern (PDRP) expressions. The PDRP expression was abnormally elevated in PD patients compared with HCs (P < 0.001). For DBS patients, a significant decrease in the Unified Parkinson's Disease Rating Scale (UPDRS, P = 0.001) and PDRP expression (P = 0.004) was observed 3months after STN DBS treatment, while a rollback was observed in both UPDRS and PDRP expressions (both P < 0.01) 12months after treatment. The changes in PDRP expression mediated by STN DBS were generally in line with UPDRS improvement. The graphical network analysis shows increased connections at 3months and a return at 12months confirmed by small-worldness coefficient. The preliminary results demonstrate the potential of metabolic network expression as complimentary objective biomarker for the assessment and monitoring of STN DBS treatment in PD patients. Clinical Trial Registration ChiCTR-DOC-16008645. http//www.chictr.org.cn/showproj.aspx?proj=13865 . The preliminary results demonstrate the potential of metabolic network expression as complimentary objective biom