https://www.selleckchem.com/products/U0126.html The somewhat surprising (R)-configured amine portion, which has been assigned to piperchabamide E (2), is facilitated by a Curtius rearrangement. Following this, the actual amine portion is shown to be (S)-configured.α-Conotoxins (Ctx) can selectively target distinct subtypes of nicotinic acetylcholine receptors (nAChRs), which are closely related to a number of neurological diseases, and they have been considered as ideal probes and model peptide drugs. Sulfotyrosine (sY) is an important post-translational modification and believed to modulate certain key protein-protein interactions. Although sY modification has been indicated in several α-Ctx, its biological consequence has largely remained unexplored, mostly because of the difficulties in both its extraction from biological samples and chemical synthesis. Herein, we report a facile synthesis and folding strategy for obtaining the sY modified α-Ctx. This strategy is based on the development of a simple and controlled deprotection of the neopentyl protecting group of the sulfate ester as well as its compatibility with a step-wise oxidative folding of the two disulfide bonds. Eight sY modified α-Ctx peptides were successfully synthesized in good yield and with high purity, and their serum stabilities were almost comparable with non-modified peptides.Photocatalytic water splitting for hydrogen production has attracted increasing research attention in recent years, and great efforts have been made in order to find the ideal photocatalyst. In this work, we proposed a two-dimensional material-based van der Waals (vdW) heterostructure constructed by vertically stacked indium selenide (InSe) and silicane (SiH) and studied the feasibility of using it as a possible photocatalyst for water splitting by using first-principles methods. The results show that the InSe/SiH is a direct band gap semiconductor with appropriate gap value and band edge position for photocatalysts in wat