Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot that plays an important role in coronary atherosclerosis. In this study, our aim was to investigate the relationship between long-term major adverse cardiovascular events (MACEs) and EAT volume detected by coronary computed tomography angiography (CCTA) in patients with Type 2 diabetes mellitus (T2-DM) without previous coronary events.
 
  A total of 127 patients with diabetes who underwent CCTA between 2012 and 2014 were enrolled retrospectively. The study population was divided into 2 groups according to whether they experienced or did not experience MACE, which was defined as cardiac death, non-fatal myocardial infarction or unstable angina requiring hospitalization, coronary revascularizations (percutaneous coronary intervention or coronary artery bypass grafting surgery), heart failure, peripheral arterial disease, or ischemic stroke. In both groups, EAT volumes were measured by CCTA.
 
  During 60±7 months follow-up period, 22 pain patients with T2-DM without previous coronary events. EAT volume may be used additionally in risk stratification for MACE besides the well-known vascular risk factors in patients with T2-DM.
  Inflammation plays a crucial role in the pathogenesis and clinical outcome of atherosclerosis. Among the various inflammatory factors, antimicrobial peptides, such as alpha-defensins, seem to contribute to the development and progression of atherosclerosis. The aim of this study was to evaluate the plasma levels of human neutrophil peptide-1, -2, and -3 (HNP1-3) in patients with acute myocardial infarction (AMI) and to assess its relationship with the severity of coronary artery disease.
 
  lasma HNP1-3 levels in patients with AMI and controls with angiographically normal coronary arteries were measured by solid-phase enzyme-linked immunosorbent assay. In the patient group, coronary artery disease severity was assessed using the SYNergy between percutaneous intervention with TAXus and cardiac surgery score (SS).
 
  HNP1-3 levels were significantly higher in the group with AMI than in the controls (6.5±5.8 ng/mL vs. 2.8±2.5 ng/mL, p<0.001). The receiver operator characteristic (ROC) analysis yielded a cut-off value of 3.13 ng/mL for differentiating patients with AMI from the controls (area under the curve 0.739, 95% confidence interval 0.629-0.831, p<0.001). HNP1-3 levels in the high SS tertile (≥33) were slightly but statistically nonsignificantly higher than that in the low (≤22) and intermediate SS tertiles (high SS 7.0±6.1 ng/mL, intermediate SS 5.9±6.2 ng/mL, low SS 5.3±3.8 ng/mL; p=0.639).
 
  Patients with AMI had higher plasma HNP1-3 levels than the controls, but this did not show a significant correlation with angiographic disease severity. The nonsignificant trend toward higher SS in patients with higher HNP1-3 levels warrants future studies on larger populations.
 Patients with AMI had higher plasma HNP1-3 levels than the controls, but this did not show a significant correlation with angiographic disease severity. The nonsignificant trend toward higher SS in patients with higher HNP1-3 levels warrants future studies on larger populations.
  Iatrogenic aortic dissection (IAD) during coronary interventions is a rare but fatal complication. There is not enough experience and trial on this subject. In this study, we report our IAD cases and their acute, short-term, and long-term results.
 
  In this study, we screened 6,096 coronary angiographies performed in our center between February 2016 and February 2019.  https://www.selleckchem.com/products/dinaciclib-sch727965.html  Ascending aortic dissection developed in 8 patients. A total of 7 patients had computed tomographic angiography images after the event and during the follow-up. We performed 1-month and 1-year follow-up examinations.
 
  The incidence of IAD was 0.13%. The female sex ratio was as 63%. A total of 37% of the patients had presented with acute coronary syndrome. In 37% of the patients, dissection occured while support catheter use, but in the remaining patients, dissections developed owing to hydraulic pressure. Regardless of the Dunning staging, 7 patients were followed-up with medical treatment, and 1 patient with decreased coronary flow was referred to emergency coronary bypass surgery. Regression was in the first tomography in 4 patients and observed in the control tomography in the remaining patients with medical treatment. The in-hospital 1-month and 1-year mortality rates were 0%.
 
  IAD is a fatal disease, and conservative follow-up is suggested due to lack of clear management recommendations. The findings in our study showed that medical treatment is the first choice for the hemodynamically stable patients when dissection is sealed by stenting; however, surgical treatment is required in patients with the decreased coronary flow.
 IAD is a fatal disease, and conservative follow-up is suggested due to lack of clear management recommendations. The findings in our study showed that medical treatment is the first choice for the hemodynamically stable patients when dissection is sealed by stenting; however, surgical treatment is required in patients with the decreased coronary flow.
  Aortic stenosis (AS) is a progressive disease, and valve replacement-the only treatment option-should be performed after it becomes symptomatic and before irreversible myocardial damages develop. Surgical valve replacement is recommended in patients with very severe AS (VSAS), even if they are asymptomatic. However, there is no detailed study on the effect of transcatheter aortic valve implantation (TAVI) in patients with VSAS. Our aim in this study is to show the feasibility and safety of TAVI in symptomatic patients with VSAS.
 
  A total of 505 consecutive patients with symptomatic AD who underwent TAVI in our center were retrospectively studied. The mean age of the patients was 77.8±7.6 years, and 56.4% of them were women. The patients were divided into 2 groups a group with VSAS (n=134 patients) and a group with high-gradient AS (HGAS) (n=371 patients).
 
  Female sex, left ventricular ejection fraction, small left ventricle, hypertrophic left ventricle were more common in the group with VSAS; on the other hand, histories of coronary artery disease bypass surgery, myocardial infarction, and atrial fibrillation were less frequent.