https://www.selleckchem.com/products/VX-702.html Central venous catheterization of children is often a challenging procedure due to small anatomical structures. Ultrasound guidance has been shown to reduce complications and improve cannulation success as compared with the landmark-based technique. In-plane techniques allow for longitudinal visualization of the vessels and real-time visualization of needle track during its advancement. When in-plane and syringe-free techniques are combined, advancement of the guidewire can also be visualized. We aim to introduce our supraclavicular approach for brachiocephalic vein cannulation in pediatric patients. A syringe-free and in-plane technique is used to cannulate the patients. The subclavian, jugular, and the brachiocephalic veins were visualized by endocavity micro-convex ultrasound probe as a Y shape during the cannulation procedure. We present a case series of successful cannulation by using this technique.Prenylated chalcones are a family of natural chalcones that have been reported to exhibit a high antioxidant activity. In this paper, the density functional calculations are carried out to study, systematically, the antiradical properties of four prenylated natural chalcones namely isobavachalcone (I), xanthohumol (II), desmethylxanthohumol (III) and broussochalcone (IV). The radical scavenging ability of all the possible CH and OH bonds of chalcones I-IV were discussed in detail thermodynamically and kinetically. The results reveal that the CH bonds of the prenyl substituent are the most thermodynamically preferred sites for free radical attack and thus play an important role on the antiradical activity of the investigated chalcones. For the OH bonds, it has been found that the B ring is more preferred for attacking free radicals than the A ring. Kinetic investigations have revealed that the CH bond and the OH bonds of the B ring can trap HO•/HOO• radicals. These results are of great significance in better understand