The short-form version of New Knee Society Score (SF-NKSS) was designed with a purpose to reduce respondent burden. Literature review revealed only one report by Scuderi et al on responsiveness of derived SF-NKSS, but it was evaluated in two separate patient cohorts pre- and postsurgery. Our study had evaluated responsiveness and convergent validity of derived SF-NKSS in a single, large patient cohort followed longitudinally from preoperative status to over 1 year.  https://www.selleckchem.com/products/colcemid.html  Our database of 148 knee arthroplasty patients operated by the same surgeon, whose NKSS, Western Ontario and McMaster Universities Arthritis Index (WOMAC), and 12-item Short-Form Survey (SF-12) scores were prospectively collected preoperatively and postoperatively at 3 and 12 months for a study published earlier, was analyzed for derived SF-NKSS. Responsiveness was evaluated by determining the effect size, standardized response mean (SRM), and ceiling and floor effects. For convergent validity, Pearson's correlation coefficient was used. SF-NKSS was found to be most responsive with the largest effect size and SRM at 3 months (3.02 and 2.50, respectively) and at 12 months (3.58 and 2.92, respectively) with no ceiling or floor effect. SF-NKSS was followed in responsiveness by original NKSS, WOMAC, and SF-12 in a descending order. Convergent validity showed a strong correlation (r = 0.8-1.0; p  less then  0.001) of SF-NKSS with NKSS and a moderate to strong correlation (r = 0.5-0.6; p  less then  0.001) with WOMAC and SF-12. We concluded that SF-NKSS is a reliable, highly responsive tool for post-total knee replacement evaluation. It also has the ability to register improvement in the patient's recovery, which can continue even after 1 year. We found that the SF-NKSS can be used interchangeably with the original NKSS. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.The study aims to provide an up-to-date systematic review and meta-analysis comparing radiological and functional outcomes of total knee arthroplasty (TKA) and unicompartmental knee arthroplasty (UKA) using either robotic assistance or conventional methods from the latest assemblage of evidence. This study was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and MOOSE (Meta-analysis of Observational Studies in Epidemiology) guidelines. All studies in PubMed, EMBASE, Medline, and Cochrane that reported radiological and functional outcomes after TKA or UKA with either robotic or conventional methods were included in the review. Selected endpoints for random effects, pairwise meta-analysis included operative details, radiological outcomes (mechanical axis, component angle deviation, and outliers), and functional outcomes (American Knee Society Score, Knee Society Function Score, revision and complication rate, range of motion (ROM), Hospital for Special Surgery sformer. Larger prospective studies with mid- and long-term outcomes are required to further substantiate findings from the present study. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.OBJECTIVE  The aim of the study is to perform a systematic review on the recent available evidence on antiphosphatidylserine/prothrombin (aPS/PT) antibodies and their association with clinical manifestations of the antiphospholipid syndrome (APS). METHODS  A detailed literature search was applied a priori to Ovid MEDLINE, In-Process and Other Non-Indexed Citation 2012 to present and to abstract from EULAR and ACR/ARHP Annual Meetings (2012-2019). RESULTS  Data from 2,901 patients, 587 diseases controls and 559 healthy controls included in 15 retrieved studies was analyzed. The patient population included 1,219 patients classified as APS according to the Sidney criteria, 285 patients with isolated persistently positive antiphospholipid antibodies (aPL) and 1,397 patients with a clinical suspicion of APS. Twelve studies, including 1,888 patients, analyzed the association between aPS/PT antibodies and thrombosis. We observed a statistically significant association between aPS/PT IgG/IgM positivity and thrombotic events (mean odds ratio [OR] 6.8 [95% CI 3.18-16.4], p  less then  0.05), confirmed when analyzing aPS/PT IgG (mean OR 6.7 [95% CI 3.04-21.6], p  less then  0.05) and aPS/PT IgM (mean OR 4.35 [95% CI 1.54-17.77], p  less then  0.05) separately. Seven studies, including 1,388 patients, evaluated the association between aPS/PT antibodies and PM. When pooled together, we found a statistically significant association between any PM and aPS/PT IgG/IgM positivity (mean OR 10.6 [95% CI 3.54-35.38], p  less then  0.05), particularly aPS/PT IgG positivity (mean OR 6.7 [95% CI 3.04-21.6], p  less then  0.05). CONCLUSION  Our results highlight the strong association between aPS/PT and the clinical manifestations of APS. With the available level of evidence, aPS/PT testing can be considered as a robust test applicable in the investigation of patients suspected for APS, also beyond the research settings. Georg Thieme Verlag KG Stuttgart · New York.INTRODUCTION  A phase 3b extension study evaluated the long-term safety and efficacy of a recombinant fusion protein-linking coagulation factor IX (FIX) with albumin (rIX-FP) for the routine prophylaxis and on-demand treatment of bleeding in pediatric hemophilia B patients. METHODS  Previously treated patients aged 7.2 IU/dL. No patient developed an inhibitor. CONCLUSION  This extension study demonstrated the long-term safety and efficacy of weekly rIX-FP in pediatric patients. Additionally, it showed that adequate bleed protection can be achieved with 10- or 14-day rIX-FP regimens in selected pediatric patients while maintaining safety. Georg Thieme Verlag KG Stuttgart · New York.BACKGROUND  Treatments of Zenker's diverticulum aim to dissect the cricopharyngeal muscle, removing the underlying source of dysfunction. This is difficult in patients with a short-septum (≤ 20 mm) diverticulum because the limited anatomical space restricts the operating area for either rigid or flexible endoscopic approaches. The aim of this study was to investigate the efficacy and safety of a novel third-space approach, peroral endoscopic septotomy (POES), for treating symptomatic patients with short-septum Zenker's diverticulum. METHODS  All patients with short-septum Zenker's diverticulum who were referred for endoscopic repair from September 2017, were considered for the study. Outcomes included procedure-related adverse events and symptom improvement. The Dakkak - Bennett score was used to quantify dysphagia. RESULTS  20 patients (men 12, women 8; mean age 67.9 years [SD 14.3]) underwent POES. All procedures were performed with patients under deep sedation. Mean size of Zenker's diverticulum was 17.5 mm (SD 3.