https://www.selleckchem.com/products/SB-203580.html The effective elastic modulus and compressive strength of scaffolds have been calculated as 1.1 ± 0.9 GPa and 37 ± 13.5 MPa with progressive failure for homogeneous structured scaffold; and 1.8 ± 0.9 GPa and 71 ± 9.5 MPa for gradient-structured scaffold with saw-tooth fracture mode and sudden incognito failure zones. The finite element analysis reveals more bulk stress onto the gradient scaffolds when compared to the homogeneous counterpart. The findings demonstrate that as-produced composite ceramic scaffolds can pave the way for treating specific orthopaedic defects by tailoring the design through additive manufacturing.Novel fibrous materials from polylactide (PLA) and Schiff base from Jeffamine ED® and 8-hydroxyquinoline-2-carboxaldehyde (Jeff-8Q) or its complex with Cu2+ (Jeff-8Q.Cu2+) were successfully prepared by using one-pot electrospinning or electrospinning combined with dip-coating. These approaches enabled the fabrication of materials of diverse design non-woven textile in which Jeff-8Q or Jeff-8Q.Cu2+ was predominantly in the fibers' bulk (type "in") or was deposited as a thin film on the surface of the fibers (type "on"). The morphology of the mats and chemical composition of their surface were analyzed by means of scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). The coordination of Cu2+ ions in Jeff-8Q.Cu2+/inPLA and Jeff-8Q.Cu2+/onPLA mats was examined by electron paramagnetic resonance (EPR) spectroscopy. It was found that the in vitro release of Jeff-8Q (Jeff-8Q.Cu2+) from the type "on" mats was more rapid than that of the type "in" mats. Enhancement of the antioxidant activity of the Jeff-8Q.Cu2+-containing fibrous mats as compared to mats containing Jeff-8Q was observed. In contrast to the neat PLA mat, the Jeff-8Q- and Jeff-8Q.Cu2+-containing mats (both type "in" and "on") displayed high in vitro antitumor activity against human cervical HeLa cells. The obtained m