Potential customers of utilizing High-Throughput Proteomics to Underpin the Discovery involving Canine Host-Nematode Friendships.
 BACKGROUND AND OBJECTIVES The opioid epidemic has led to substantive regulatory and policy changes. Little is known about how these changes have impacted older adults, especially those with chronic pain and multiple chronic conditions (MCC). We sought to understand the experiences of older adults with chronic pain and MCC in the context of the opioid epidemic and policy responses to it. RESEARCH DESIGN AND METHODS Purposive sampling of older adults in a West Coast metropolitan area. Semistructured in-depth interviews lasting 45-120 min were digitally recorded and transcribed. Responses were analyzed using the constant comparative method. Participants were 25 adults aged 65 years and greater with three or more self-reported medical conditions and pain lasting for more than 6 months. RESULTS Respondents' accounts revealed numerous unintended consequences of the opioid epidemic and its policy responses. We identified four main themes changes to the patient-clinician relationship; lack of patient agency and access in pain management; patient ambivalence and anxiety about existing opioid treatment/use; and patient concerns about future use. DISCUSSION AND IMPLICATIONS Older adults have high rates of chronic pain and MCC that may reduce their pain management options. The opioid epidemic and policies addressing it have the potential to negatively affect patient-clinician relationships and patients' pain self-management. Clinicians may be able to mitigate these unintended consequences by actively conveying respect to the patient, empowering patients in their pain self-management activities, and proactively addressing worries and fears patients may own related to their current and future pain management regimens. © The Author(s) 2020. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Stenosis is the primary complication of current tissue-engineered vascular grafts used in pediatric congenital cardiac surgery. Murine models provide considerable insight into the possible mechanisms underlying this situation, but they are not efficient for identifying optimal changes in scaffold design or therapeutic strategies to prevent narrowing. In contrast, computational modeling promises to enable time- and cost-efficient examinations of factors leading to narrowing. Whereas past models have been limited by their phenomenological basis, we present a new mechanistic model that integrates molecular- and cellular-driven immuno- and mechano-mediated contributions to in vivo neotissue development within implanted polymeric scaffolds. Model parameters are inferred directly from in vivo measurements for an inferior vena cava interposition graft model in the mouse that are augmented by data from the literature. By complementing Bayesian estimation with identifiability analysis and simplex optimization, we found optimal parameter values that match model outputs with experimental targets and quantify variability due to measurement uncertainty. Utility is illustrated by parametrically exploring possible graft narrowing as a function of scaffold pore size, macrophage activity, and the immunomodulatory cytokine transforming growth factor beta 1 (TGF-β1). The model captures salient temporal profiles of infiltrating immune and synthetic cells and associated secretion of cytokines, proteases, and matrix constituents throughout neovessel evolution, and parametric studies suggest that modulating scaffold immunogenicity with early immunomodulatory therapies may reduce graft narrowing without compromising compliance. © The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.Okinawan sweet potato, Ipomoea batatas, is an important food staple and export crop for the Island of Hawaii. Cylas formicarius elegantulus, sweet potato weevil, is a major quarantine pest that causes severe destruction to the crop. Root malformation and a bitter taste occur when larvae feed and tunnel within the storage root. Off-grade roots are often left in the field after harvest and serve as a reservoir for the weevils. Current management involves the unsustainable practice of moving to virgin land for the next cropping cycle. Strains of Heterorhabditis indica isolated from the Hawaiian Islands were tested for their efficacy at causing mortality of C. formicarius and reducing the emergence of adults from infested roots. In well plate assays, H. indica caused mortality of 88% larvae, 96% pupae, and 4% adults after 48 h. When applied to infested roots, the nematodes caused an average mortality of 78% larvae, 66% pupae, and 32% adults.  https://www.selleckchem.com/products/Bortezomib.html  Greater mortality was observed at the highest inoculum levels (10,000 infective juveniles per storage tuber) but a reduction of 90% inoculum density was still effective at weevil management. In simulated field trials, infestation of storage roots was reduced by 42-99.6% when planted among infested roots that had been inoculated with H. indica. Rates of 2.5 billion IJs/hectare were just as effective as 5 billion IJs/hectare. Application of local H. indica strains in sweet potato production has the potential to manage C.  https://www.selleckchem.com/products/Bortezomib.html  formicarius populations and allow for consecutive cropping seasons. Published by Oxford University Press on behalf of Entomological Society of America 2020.PURPOSE To describe the process and outcomes of services or products co-produced with patients in hospital settings. DATA SOURCES Database searches on Medline, CINAHL and Business Source between 2008 and 2019. STUDY SELECTION Studies that evaluate the products of co-production in hospital settings. DATA EXTRACTION Primary outcome is the individual and organizational outcomes resulting from co-production. Study characteristics, co-production process, level of engagement and intensity of engagement were also extracted. RESULTS OF DATA SYNTHESIS A total of 13 studies were included. Types of co-produced outputs were health services and care processes, tools and resources, and technology-based products, such as mobile application. Most studies engaged patients at a consultative or involvement level, with only four studies engaging patients as partners. Moderate-to-high acceptability and usability by patients and health services were reported for co-produced outputs. Organizational outcomes were also reported qualitatively as producing various positive effects, such as improved communication and diagnostic process.