https://www.selleckchem.com/ In this work, we perform the numerical investigation of the performance of the small optical reservoir computing (RC) systems with four neurons using the commercial software for optical fiber communication system. The small optical RC system consists of the components of the optical fiber communication. The nonlinear function which is required in RC is provided by the erbium-doped optical fiber amplifiers (EDFA). We demonstrate that the EDFA should be operated in the saturated or non-linear regime to obtain a better performance of the small optical RC system. The performance of the small optical RC systems for different topological neuron structures is investigated. The results show that the interconnection between the neurons could offer a better performance than the systems without interconnection between the neurons. Moreover, the input signals with different noise levels are launched into the systems. The results show that the small optical RC system can classify the noisy input optical waveforms even when the signal-to-noise ratio is as low as - 2.55 dB.Cardiac myocytes have multiple cell autonomous mechanisms that facilitate stabilization and repair of damaged sarcolemmal membranes following myocardial injury. Dysferlin is a protein which facilitates membrane repair by promoting membrane resealing. Although prior studies have shown that dysferlin-deficient (Dysf-/-) mouse hearts have an impaired recovery from acute ischemia/reperfusion (I/R) injury ex vivo, the role of dysferlin in mediating the recovery from myocardial injury in vivo is unknown. Here we show that Dysf-/- mice develop adverse LV remodeling following I/R injury secondary to the collateral damage from sustained myocardial inflammation within the infarct zone. Backcrossing Dysf-/- mice with mice lacking signaling through the Toll-Interleukin 1 Receptor Domain-Containing Adaptor Protein (Tirap-/-), attenuated inflammation and abrogated adverse LV remodeling following I