https://www.selleckchem.com/products/elacestrant.html Although symmetry, averageness, and sexual dimorphism are usually considered important to facial attractiveness, there are mixed findings regarding whether and how symmetry influences facial attractiveness. The present study introduced "facial normality" to explain the inconsistency of previous research. We hypothesized that symmetry only increased facial attractiveness when it improved facial normality. We manipulated symmetry and normality simultaneously on sixteen Chinese male faces and asked participants to rate the perceived symmetry, perceived normality, and facial attractiveness. The results demonstrated an interactive effect of symmetry and normality on facial attractiveness. The structural equation model results showed two paths from symmetry to facial attractiveness (1) Symmetry reduced facial attractiveness by decreasing perceived normality; (2) Symmetry increased facial attractiveness by increasing the perceived symmetry and then improving perceived normality. In other words, perceived normality acted as a mediator between symmetry and facial attractiveness. The present study provides a solution to the different effects of symmetry on facial attractiveness in previous studies and suggests that future studies on symmetry and facial attractiveness should consider the mediating role of normality.The deep-sea ecosystem is considered as the largest and most remote biome of the world. It is meaningful and important to elucidate the life origins by exploring the origin and adaptive genetic mechanisms of the large deep-sea organisms. Sea cucumbers (Holothuroidea) are abundant and economically important group of echinoderms, living from the shallow-waters to deep-sea. In this study, we present the mitochondrial genomes of the sea cucumber Chiridota heheva and Chiridota sp. collected from the deep-sea cold seep and hydrothermal vent, respectively. This is the first reported mitochondrial genomes from the order