We report a single-institute experience of neonatal transvenous radiofrequency pulmonary valve perforation for pulmonary atresia/intact ventricular septum, with echocardiographic predictors of biventricular circulation. Data were reviewed retrospectively for all neonates who underwent primary transvenous pulmonary valve perforation for pulmonary atresia/intact ventricular septum between January 2008 and November 2018 at our institution. https://www.selleckchem.com/products/CP-690550.html We compared patients who need systemic-to-pulmonary shunt or ductal stenting with patients who did not need. During the study period, 31 patients with pulmonary atresia/intact ventricular septum underwent successful radiofrequency pulmonary valve perforation and balloon dilation of the pulmonary valve. There was no procedure-related mortality. Sixteen patients (52%) needed systemic-to-pulmonary shunt or ductal stenting after initial procedure. Among the survivors (follow-up time of 1 to 11.5years), 15 patients had a biventricular circulation and 6 patients had 1 and 1⁄2 atients according to tricuspid valve z-score and TV/MV annulus ratio allows predicting biventricular circulation. Childhood adaptation is essential for proper social-emotional development. Children growing up in a family context where they feel supported and protected are less vulnerable in the presence of psychopathology. The aim of this study is analysing the impact of parenting styles and the anxious-depressive symptoms on child adaptation. A total of 367 children between the ages of 10 and 12, following a similar distribution by sex. The children completed self-reports assessing parenting styles, child adaptation, and depressive-anxiety symptomatology. The data were analysed using two complementary methodologies linear regressions and fuzzy-set qualitative comparative analysis (fsQCA). Both methodologies indicated that the main predictors explaining child adaptation were depression and an authoritative parenting style. The fsQCA models explained a greater amount of variance and included more variables in their prediction than the regression models. Identifying family and emotional aspects when working with children may help professionals to improve childhood adaptation. Consequently, well-adapted children are less likely to suffer the negative consequences of emotional symptoms in later evolutionary stages. Identifying family and emotional aspects when working with children may help professionals to improve childhood adaptation. Consequently, well-adapted children are less likely to suffer the negative consequences of emotional symptoms in later evolutionary stages.Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1 R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1 R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity. Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in adults. In this study, we aimed to show the relationship between temporal muscle thickness (TMT) measurement and survival in newly diagnosed patients with GBM. Forty-seven patients with newly diagnosed GBM were evaluated, retrospectively. TMT at diagnosis of GBM before any surgical procedure was measured on the contrast-enhanced axial longitudinal relaxation time (T1)-weighted magnetic resonance images. Overall survival (OS) was analyzed by the Kaplan-Meier method and log-rank test was used to determine the differences between the groups. The median TMT was used to determine the cutoff point. The median TMT was 4.7mm (range, 2.8-6.6) in females and 5.4mm (range, 2.9-8.1) in males. Median survival for TMT<4.9mm was 12.9±3.5 (95% CI, 6.0-19.8) months, and 39.4±11.9 (95% CI, 16.0-62.8) months for TMT ≥4.9 (P=.023). In the multivariate Cox regression model, the TMT group (Hazard ratio [HR]=2.07, 95% CI, 0.92-4.61, P=.032) and age group (HR=2.18, 95% CI, 1.01-4.67, P=.014) showed statistically significant difference. TMT is not an independent predictor of response but a predictor of sarcopenia and survival in newly diagnosed GBM. TMT measurement is an easy and practical method. Survival prediction will provide useful information in GBM patients having poor prognosis. TMT is not an independent predictor of response but a predictor of sarcopenia and survival in newly diagnosed GBM. TMT measurement is an easy and practical method. Survival prediction will provide useful information in GBM patients having poor prognosis. The metabolic behavior and the prognostic value of F-FDG-PET/CT in gastrointestinal stromal tumor (GIST) is not well investigated. The aim of this study was to analyze the metabolic behavior of GIST and the prognostic role of pretreatment PET/CT features. In this retrospective study, we included 35 patients with a diagnosis of GIST who underwent a pretreatment F-FDG-PET/CT scan. We analyzed PET images visually and semiquantitatively by measuring several metabolic parameters as the maximum standardized uptake value corrected for body weight (SUVbw), for lean body mass (SUVlbm), for body surface area (SUVbsa), metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The Kaplan-Meier method was used to measure the progression free survival (PFS) and overall survival curves. Twenty-nine (82%) patients showed a positive F-FDG-PET/CT, whereas the remaining 6 had no hypermetabolic lesions. F-FDG-avidity was significantly related with mitotic index, tumor stage and tumor risk group. Instead, semiquantitative PET/CT parameters correlated only with tumor risk group.