https://www.selleckchem.com/products/fluorofurimazine.html 234 participants maintained viral suppression through 96 weeks (90% male, 29% Black, median age 36 years). Serum leptin increased over 96 weeks (mean change 22%) while adiponectin did not (mean change 1%), which did not differ by study arm. Greater trunk, limb, and abdominal subcutaneous and visceral fat were associated with higher HOMA-IR and hsCRP at 96 weeks, but serum leptin level was a stronger determinant of these endpoints using a mediation model approach. A similar mediating effect was not observed for adiponectin. Higher circulating leptin is associated with greater HOMA-IR and hsCRP independent of fat depot size, suggesting greater adipocyte lipid content may contribute to impaired glucose tolerance and systemic inflammation among PWH starting ART. Higher circulating leptin is associated with greater HOMA-IR and hsCRP independent of fat depot size, suggesting greater adipocyte lipid content may contribute to impaired glucose tolerance and systemic inflammation among PWH starting ART. Based on the WHO Age-friendly Cities and Communities (AFCC) framework, the government of Manitoba, Canada, launched a province-wide age-friendly initiative in 2008. The objective of this study was to explore the sustainability of the AFCC initiative more than a decade later. The study was guided by conceptualizations of sustainability as multi-dimensional and dynamic, composed of four aspects (continued capacity; institutionalization; continued benefits; and development/adaptation), and an ecologic perspective that highlights the importance of contextual influences, and their change over time, on AFCC activities. The study involved a qualitative, multiple case study design. Semi-structured interviews were conducted in 2020 with a key informant from each of 52 AFCC. Interview data were analyzed deductively, guided by the sustainability framework and an ecologic perspective. Census data was used to describe the demograph