https://www.selleckchem.com/products/bms-927711.html We implemented the Self-Organizing Maps (SOMs) algorithm running efficiently on GPUs, and also provide several clustering methods of the resulting maps. We provide scripts and a use case to cluster macro-molecular conformations generated by molecular dynamics (MD) simulations. The method is available on GitHub and distributed as a pip package. guillaume.bouvier@pasteur.fr. guillaume.bouvier@pasteur.fr. Assessing the effect of statin therapy at hospital admission for COVID-19 on in-hospital mortality. Retrospective observational study. Patients taking statins were 11 years older and had significantly more comorbidities than patients who were not taking statins. A genetic matching (GM) procedure was performed prior to analysis of the mortality risk. A Cox proportional hazards model was used for the cause-specific hazard (CSH) function, and a competing-risks Fine and Gray (FG) model was also used to study the direct effects of statins on risk.Data from reverse transcription-polymerase chain reaction-confirmed 2157 SARS-CoV-2-infected patients (1234 men, 923 women; age 67 y/o (IQR 54-78)) admitted to the hospital were retrieved from the clinical records in anonymized manner. 353 deaths occurred. 581 patients were taking statins. Univariate test after GM showed a significantly lower mortality rate in patients on statin therapy than the matched non-statin group (19.8% vs. 25.4%, χ2 with Yates continuity correction p = 0.027). The mortality rate was even lower in patients (n = 336) who maintained their statin treatments during hospitalization compared to the GM non-statin group (17.4%; p = 0.045). The Cox model applied to the CSH function (HR = 0.58(CI 0.39-0.89); p = 0.01) and the competing risks FG model (HR = 0.60(CI 0.39-0.92); p = 0.02) suggest that statins are associated with reduced COVID-19-related mortality. A lower SARS-CoV-2 infection-related mortality was observed in patients treated with statin therapy prior