Acinar cell cystadenoma (ACA) is very rare and benign neoplasm of the pancreas; it arises from the normal acinar parenchyma of the pancreas and may exist as solitary or diffuse lesions.
 
  We here present a case of thirty-seven years old gentleman who incidentally was found to have multifocal cystic lesions distributed throughout the tail, body and uncinate process of the pancreas.
 
  Pre-operative diagnosis of pancreatic ACA remains very difficult and challenging despite advances in imaging techniques. Due to diffuse involvement of the pancreas by different size cystic lesions in this case, the initial diagnosis was suspected to be SB-IPMNs. A Surgical resection was performed, and pathological analysis of the lesions was consistent with ACAs.
 
  To avoid unnecessary major pancreatic resection and its consequent complications. We hereby recommend clinicians to have a high index of suspicion for ACA within the differential of pancreatic cystic neoplasm.
 To avoid unnecessary major pancreatic resection and its consequent complications. We hereby recommend clinicians to have a high index of suspicion for ACA within the differential of pancreatic cystic neoplasm.
  Sarcomatoid renal cell carcinoma (sRCC) represents a rare form of renal cell carcinoma marked by an aggressive biology, poor prognosis and little benefit from anti-angiogenic targeted therapy. More promising results come from the recent therapeutic strategy based on immune checkpoint inhibitor (ICI) combinations.
 
  For this meta-analysis, we searched MEDLINE/PubMed, the Cochrane Library and American Society of Medical Oncology (ASCO) Meeting abstracts for phase II or III randomised clinical trials. Data extraction was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis statement. The hazard ratios (HRs) for progression-free survival (PFS) and overall survival (OS) with the relative 95% confidence intervals were extracted from studies. Summary HRs were calculated using random- or fixed-effects models, depending on the heterogeneity of the included studies.
 
  Four studies were selected for final analysis, including 467 patients (226 treated in with ICI combinations and 241 received sunitinib in the control arms). ICI-based combinations were associated with an improved PFS and OS compared with sunitinib, with a reduction of more than 40% of progression (HR=0.56; p<0.0001) and mortality (HR=0.56; p=0.001) risk. Moreover, ICI-based combinations are associated with a objective response rate (ORR) of more than 50% (versus 20% with sunitinib), corresponding to a doubled risk of achieving an ORR compared with controls (relative risk [RR]=2.15; p<0.00001).  https://www.selleckchem.com/products/otx015.html  Finally, immunotherapy significantly increased the possibility to obtain complete responses(RR=8.15, p=0.0002) with an incidence of 11%.
 
  Our data support the efficacy of ICI-based combinations for sRCC therapy, redefining the first-line treatment.
 Our data support the efficacy of ICI-based combinations for sRCC therapy, redefining the first-line treatment.The wetting and adsorption properties for two glycoproteins, recombinant human lubricin and bovine submaxillary mucins (BSM) were evaluated on hydrophilic and hydrophobic glass dome surfaces in a simplified in vitro tear film model. We show that both recombinant human lubricin (rh-lubricin) and BSM solutions render surfaces hydrophilic and when the fluid films reach 500 nm or less, the fluids resist evaporation-driven breakup through a volumetric flux across the surface, which we believe is due to evaporation-driven solutocapillary flows. rh-Lubricin was able to maintain a wet film without spontaneous breakup for longer periods of time than BSM at lower concentrations, which we attribute to differences in adsorption properties, measured by QCM-D, that result from surface charge and structural differences (confirmed by zeta potential, DLS, and SAXS measurements).Nuclear magnetic resonance (NMR) provides useful information for formation evaluation on pore size and pore volume. Depending on field operations, there are two types of borehole NMR wireline logging and logging-while-drilling (LWD). The latter type is more convenient. But due to the high mechanical failure risk caused by insufficient mechanical strength of the tool and vibrations during measurement, the quality of LWD NMR measurements are severely affected. In this paper, to enable high reliability and vibration tolerance, we propose a new design and implement a new LWD NMR tool, whose features includes a double hollow cylindric magnet (DHCM) structure and a solenoid-optimized antenna. The DHCM structure greatly reduces the proportion of the magnet in the cross-section of the tool without reducing B0 field strength. Thus, the mechanical strength and the reliability of the tool is greatly improved. The antenna is improved by optimizing the parameters of each coil of the solenoid for finding the generated B1 distribution best matching B0. The new design has a saddle sensing area in the axial and radial plane with a width greater than 50 mm, which is wide enough to ensure the validity of the T2 measurement under strong vibrations. We had demonstrated that this new tool performs well when TE = 0.6 ms, ensuring the measurement richness is suitable for LWD prospecting for unconventional oil and gas reservoirs. Besides, this design is suitable for that in slim holes.The actual diffusion process in human brain has been shown to be anomalous comparing to that predicted with traditional diffusion MRI (dMRI) theory. Recently, dMRI based on fractional motion (FM) model has demonstrated the potential to accurately describe anomalous diffusion in vivo. In this work, we explored the potential value of FM model-based dMRI in quantificational identification of ischemic stroke and compared that with the traditional apparent diffusion coefficient (ADC). We included 23 acute stroke patients, 8 of whom finished a follow-up scan, and 22 matched healthy controls. The dMRI images were acquired by using a Stejskal-Tanner single-shot spin-echo echo-planar-imaging sequence (diffusion gradients were applied in three orthogonal directions with 25 non-zero b values ranging from 248 to 4474 s/mm2) at 3.0 T MRI. We calculated the coefficient of variation (CV) for FM-related parameters in stroke lesions, and compared the mean values for FM-related parameters and ADC by using two-sample t-tests. Correlation analysis was achieved using Pearson correlation coefficient test.