https://www.selleckchem.com/products/mcc950-sodium-salt.html 001) than the TBI patients who were not COVID-19 positive. Other variables such as hypotension (OR, 4.57P<0.001), hyperglycemia (OR, 2.39, P=0.002), and use of anticoagulant drugs (OR, 2.41P=0.001) were also associated with in-hospital death.According to the binary logistic regression analysis Age (OR, 1.72; 95% CI 1.26-2.18; P=0.033), Coronavirus infection (OR, 2.21; 95% CI 1.83-2.92; P=0.011) and Glasgow Coma Scale (GCS) (OR, 3.11; 95% CI 2.12-4.53; P<0.001) were independent risk factors correlated with increased risk of in-hospital mortality of elderly patients with moderate to severe TBI. Our results showed that Coronavirus infection could increase the risk of in-hospital mortality of elderly patients with moderate to severe TBI significantly. Our results showed that Coronavirus infection could increase the risk of in-hospital mortality of elderly patients with moderate to severe TBI significantly. A review of the literature with respect to pituitary metastases (PM) with clinical and radiological considerations are summarized to facilitate clinical decision making in the management of PM METHODS A review of literature associated with PM and tumour to tumour metastases in the English literature was reviewed and summarized RESULTS Pituitary metastases account for 1.0-3.6% of all surgically treated pituitary lesions. Often identified in parallel with extensive disseminated disease, once diagnosed, the prognosis is generally poor, although survival is highly heterogeneous and dependent on the primary tumor histology. Within this anatomical region is also the observation of tumor-to-tumor metastases and collision tumours. Both the tumor macro- and microenvironment play central roles to the progression of disease with distinctive radiological features that may suggest a metastatic sellar lesion as opposed to a primary pituitary lesion. Surgical resection is the first line of therapy followed by adjuvant chey