https://www.selleckchem.com/products/ezatiostat.html This approach has the advantage of using the information in the third mode to solve the peak co-elution problem without the need for peak alignment among samples. With the proposed approach, it was possible to study the degradation of calcium rosuvastatin, a modern cholesterol lowering drug, using a 2 min-run, despite all the challenges in the modelling of this data. The proposed strategy was compared to an approach based on augmenting the matrix in the spectral/kinetic modes (second order modelling strategy).This paper describes a simple and reliable method for the sensitive and selective determination of the pesticides Glyphosate and Glufosinate and their main metabolites aminomethylphosphonic acid (AMPA) and 3-[hydroxy(methyl)phosphinoyl]propionic acid (MPPA) in surface water. The developed method is based on ion chromatography hyphenated to electrospray tandem mass spectrometry and does not require derivatization. A membrane suppressor, regenerated at pH 9, has been used in this work to strongly improve the peak shape of AMPA, which suffered from huge tailing due to the interaction of this compound with acidic membrane suppressors. With modified suppressor the sensitivity for AMPA improved about 100 times. Moreover, addition of 40% methanol to the hydroxy eluent improved MS sensitivity for all compounds by 1.3-2.8 times. #link# The separation is performed on a strong anion exchange column. Glyphosate and AMPA are detected in the negative ion ESI mode, whereas Glufosinate and MPPA show much better sensitivity in recovery (94-104%) and reproducibility variance (5.5-6.2%) were excellent. The suitability of the developed method was demonstrated by the analysis of 172 surface water samples of low to moderate salinity from different parts of The Netherlands. AMPA was identified in 99% of the samples and always exceeded the maximum allowable concentration of 100 ng L-1. The maximal concentration found in surface wate