https://www.selleckchem.com/products/ws6.html 005) and 1 year (92.9 ± 4.9 vs. 88.1 ± 4.6, P less then 0.001), but not at the latest follow-up (P = 0.081). Ankle ROM was markedly improved in the ARPF group unlike in the ORIF group at 6 months (dorsiflexion P = 0.025; plantar flexion P less then 0.001) and 1 year (dorsiflexion and plantar flexion P less then 0.001). The improvement remained present at the latest follow-up in plantar flexion (P = 0.001) but not in dorsiflexion (P = 0.354). CONCLUSIONS Arthroscopy-assisted reduction is a feasible alternative modality with superior short-term outcomes for treating isolated medial malleolar fracture, but its superiority may be attenuated in the intermediate term. PURPOSE To quantify the effects of lateral extra-articular tenodesis (LET) on tibiofemoral compartment contact area and pressures, knee kinematics and forces. METHODS Nine cadaveric knees were tested using a robotic testing system. Two loading conditions, 1) anterior tibial translational load coupled with axial compression and 2) internal tibial torque coupled with axial compression were applied for each knee state at full extension, 30º, 60º and 90º of knee flexion. Kinematic data was recorded for three knee states ALC competent, ALC deficient , and post-LET using a 6-mm semitendinosus graft. In situ force in the ACL was quantified using the principle of superposition by comparing the change in force measured before and after the removal of the ALC. Contact area and pressures in each tibiofemoral compartment was measured by replaying kinematics after soft tissues were removed and pressure sensors inserted. RESULTS In response to an anterior tibial translational load, mean contact area in the medial compartment decreased by 33.1% from the ALC competent to post-LET knee states at 90º of knee flexion (P = .042). No significant differences in the lateral compartment contact pressure were found between knee states. In situ force in the ACL in response to an anterior