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https://www.selleckchem.com/products/hydroxychloroquine-sulfate.html Significant progress has been achieved on perovskite nanocrystal (PNC)-converted light-emitting diodes (PcLEDs) with the development of surface encapsulations. However, achieving bright and long-living devices remains a challenge because the thermal isolation structure of the air barriers exacerbates heat accumulation inside PcLEDs. Here, we proposed a thermal conductive encapsulation for PNCs by embedding CsPbBr3 PNCs in layer-by-layer assembled boron nitride (BN) nanoplatelets through SiO2 crosslinking. This structure effectively suppresses the heat accumulation on PNCs and provides excellent air resistance, enabling the PNC-SiO2-BN composite to withstand 1000 h of photothermal annealing (under a 405 nm laser at 0.31 W cm-2, 80 °C in air) without showing obvious degradation. Green- and white-light PcLEDs were fabricated via on-chip encapsulation of PNC-SiO2-BN. The PcLEDs achieved the milestone in long-term stability (half-life time > 1000 h) at a high power density of ∼1.7 W cm-2 and displayed extradentary stability at ∼0.15 W cm-2 with constant light intensity within 1000 h of sustained illumination. The success in making thermal conductive composites will expedite the application of PNCs in LED backlights and other optoelectronic devices.Cross-linking of living cells followed by mass spectrometry identification of cross-linked peptides (in situ CLMS) is an emerging technology to study protein structures in their native environment. One of the inherent difficulties of this technology is the high complexity of the samples following cell lysis. Currently, this difficulty largely limits the identification of cross-links to the more abundant proteins in the cell. Here, we describe a targeted approach in which an antibody is used to purify a specific protein-of-interest out of the cell lysate. Mass spectrometry analysis of the protein material that binds to the antibody can then identify considerabl

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