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https://www.selleckchem.com/products/sodium-2-1h-indol-3-ylacetate.html 05) and as a predictor of clinicopathological variables. In patients with PTC, solute carrier gene expression showed differential associations with clinicopathological variables. The 5 genes could be used as prognostic factors for PTC, particularly to predict PTC recurrence. Two new protocols have been developed for bicycle exercise testing in chronic obstructive pulmonary disease (COPD) with an individualized cardiopulmonary exercise test (ICPET) and subsequent customized endurance test (CET), which generate less interindividual spread in endurance time compared with the standard endurance test. Main objectives of this study were to improve the prediction algorithm for for the ICPET and validate the CET by examining treatment effects on exercise performance of indacaterol/glycopyrronium (IND/GLY) compared with placebo. COPD patients, with forced expiratory volume in 1 s ( ) 40-80% predicted, were recruited. Pooled baseline data from two previous studies (  = 38) were used for the development of an improved prediction algorithm. Additional COPD patients (  = 14) were recruited and performed the ICPET, using the new prediction formula at visit 1. Prior to the CET at visits 2 and 3, they were randomized to a single dose of IND/GLY (110/50 µg) or placebo. The improved multiple regression algorithm for includes diffusing capacity for carbon monoxide ( ), , , and and correlated to measured (  = 0.89 and slope = 0.89). Treatment with IND/GLY showed improvement in endurance time placebo, mean 113 s [95% confidence interval (CI) 6-220],  = 0.037, with more prominent effect in patients with  < 70% predicted. The two new protocols for ICPET (including the new improved algorithm) and CET were retested with consistent results. In addition, the CET showed a significant and clinically relevant prolongation of endurance time for IND/GLY placebo in a small number of patients. The two new protocols for ICPET (in

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