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https://www.selleckchem.com/products/ABT-263.html PURPOSE To analyze the clinical characteristics, management choices, and outcomes of cases of methicillin-resistant Staphylococcal aureus (MRSA) keratitis. DESIGN Retrospective interventional case series METHODS 52 culture-proven (52 eyes) cases of MRSA keratitis diagnosed and treated at the University of Pittsburgh Medical Center were identified and reviewed. RESULTS Mean age was 66.6±19.2 years with median follow-up time of 147 days. The most prevalent risk factors included a history of ocular surgery (62.5%), topical corticosteroid use (35.4%), and dry eye syndrome (37.5%). There was a high burden of systemic disease (95.8%). Average presenting logMAR visual acuity was 1.7±0.8 and average final logMAR visual acuity was 1.2+1.0. Initial antibiotic treatment varied, with 20.8% receiving moxifloxacin alone, 20.8% fortified cefazolin and fortified tobramycin together, and 12.5% fortified vancomycin and fortified tobramycin, though other antibiotics were used during treatment if warranted. Surgical management was often required as 17.3% of eyes perforated 13.5% required tarsorrhaphy, 5.8% required penetrating keratoplasty, and 1 eye was enucleated. When patients treated with fourth-generation fluoroquinolones were compared to those treated with fortified vancomycin, no difference in final visual acuity, treatment duration, or need for surgery was found. CONCLUSIONS MRSA causes fulminant keratitis often requiring surgical management with poor visual acuity outcomes. Poor ocular surface, topical corticosteroid use, prior ocular surgery, and/or a high burden of systemic disease were identified as common risk factors. Patients treated with fluoroquinolones in our study had comparable outcomes to those treated with fortified vancomycin, however, those treated with fortified vancomycin tended to have more severe ulcers at presentation. PURPOSE Few studies have measured the incidence and risk factors of intraocular lens (IOL)

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