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https://www.selleckchem.com/ ith or without FoG had similar difficulties standing quietly on an unreliable surface compared to healthy controls. Wearable inertial sensors can reveal worse fLoS in freezers than non-freezers that may contribute to FoG and help explain their more frequent falls. Understanding the contribution of anticipatory postural adjustments (APA) to walking ability in individuals with Huntington's disease (HD) may provide insight into motor planning and the functional consequences of HD-specific cortical-basal ganglia pathway dysfunctions. How do inertial measurement unit (IMU)-derived APAs and first step parameters differ between individuals with HD and non-HD peers under no load and cognitive load conditions, and what is their relationship to gait speed and clinical measures? 33 individuals with manifest HD and 15 non-HD peers wore three Opal APDM IMUs during a 14-meter walk under no load and cognitive load conditions. APA acceleration amplitudes, APA durations, first step range of motion (ROM), and first step durations were compared, along with their relationship to gait speed. Individuals with HD had greater APA acceleration amplitudes, smaller first step ROM and longer first step durations compared to non-HD peers. No differences in APA durations were present betwees of HD-related movement scaling. Visual information is a contributing factor affecting human gait and balance, especially in low lit environments. To mitigate the adverse effects of poor lighting conditions and help older adults perceive their positions in a community-dwelling setting, destination-based visual perceptual cues were designed as a specific lighting intervention and the effectiveness of the lighting intervention was tested in this study. 1) Does the designed lighting intervention improve older adults' walking performance? 2) Does the designed lighting intervention change older adults' walking strategy? Fifteen community-dwelling older adults (165.5 ± 9.3 cm, 6 males,

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