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https://www.selleckchem.com/products/ttnpb-arotinoid-acid.html To describe the baseline participant characteristics in the ASPREE-AMD study, investigating the effect of aspirin on AMD incidence and progression. Australian participants from the ASPirin in Reducing Events in the Elderly (ASPREE) trial, randomized to 100mg aspirin daily or placebo, had non-mydriatic, digital color fundus images graded according to the Beckman AMD classification. Associations with AMD were determined for baseline characteristics and genetic risk variants. ASPREE-AMD sub-study enrolled 4993 participants with gradable macular images. Median age was 73.4 years (IQR, 71.5, 76.6), 52% were female, 10% had diabetes mellitus, 73% had hypertension, and 44% were former/current smokers. Early, intermediate and late AMD (detected in 20.6%, 16.1%, 1.1%, respectively), significantly associated with age, were also associated with increasing HDL levels OR=1.52 (95%CI, 1.26, 1.84), OR=1.43 (1.17, 1.77) and OR=1.96 (1.02, 3.76), respectively. Female sex was associated with early [OR=1.37 (1.16, 1.62)], and intermediate [OR=1.35 (1.12, 1.63)] AMD, as was previous regular use of aspirin, with OR=1.46 (1.11, 1.92) and OR=1.37 (1.01, 1.85), respectively. Current smoking had increased odds for late AMD, OR=4.02 (1.42, 11.36). Genetic risk variant rs3750846 ( ) was associated with each AMD stage ( <0.001), risk variants rs570618 and rs10922109 ( with intermediate and late AMD ( <0.001), and rare variant rs147859257 ( ) with late AMD ( <0.001). The randomized groups were well balanced for all analyzed AMD risk factors. Observed associations are typical of AMD. The ASPREE-AMD clinical trial provides a unique opportunity to determine the risks and benefits of low-dose aspirin for AMD incidence and progression in elderly population. Australian New Zealand Clinical Trial Registry ACTRN 12613000755730. Australian New Zealand Clinical Trial Registry ACTRN 12613000755730. Recent reports on catheter ablation for prema

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