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https://www.selleckchem.com/products/pt2399.html mposites, or were not sure about the appropriate cementation protocol.Purpose To compare the 2-year cumulative survival rates of class II restorations made according to Atraumatic Restorative Treatment (ART) with axial grooves and the high-viscosity glass-ionomer cement (HVGIC) Equia Fil (GC) and the conventional method using the resin composite Filtek Z250 (3M Oral Care). Materials and Methods A parallel-group study design and a stratified randomization process (DMFS count and cavity size) were applied. Restorations were evaluated according to the ART restoration and USPHS criteria. Data were statistically analyzed using the proportional hazard rate regression model with frailty correction. Results 272 class II restorations were placed in 131 people (mean age 26.2 years) by two dentists. The dropout rate of restorations was 2.6%. According to ART restoration and USPHS criteria, the 2-year cumulative survival rates of class II ART/HVGIC restorations were 96.2% and 97.0%, respectively, and 97.8% and 98.5%, respectively, for the conventional class II resin-composite restorations. No differences were observed in the cumulative survival rates between the two treatment groups at 2 years (ART criteria p=0.26; USPHS criteria p=0.23). Conclusion HVGIC Equia Fil used in the ART method with axial grooves and Filtek Z250 in the conventional method provided high survival rates for restoring class II cavities over 2 years.Raloxifene is a selective estrogen receptor modulator (SERM) that is used to manage osteoporosis in women. Because of its tissue selectivity, raloxifene has fewer side effects than estrogen therapy; however, raloxifene-associated osteonecrosis of the jaw (ONJ) has recently been reported. While most of the reported cases were treated with antiresorptive therapy in addition to raloxifene, ONJ can also occur with the isolated use of raloxifene. This report presents a case where there was no prior exposure to bispho

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