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https://www.selleckchem.com/products/AZD2281(Olaparib).html This paper proposes a compact, high-linearity, and reconfigurable continuous-time filter with a wide frequency-tuning capability for biopotential conditioning. It uses an active filter topology and a new operational-transconductance-amplifier (OTA)-based current-steering (CS) integrator. Consequently, a large time constant τ , good linearity, and linear bandwidth tuning could be achieved in the presented filter with a small silicon area. The proposed filter has a reconfigurable structure that can be operated as a low-pass filter (LPF) or a notch filter (NF) for different purposes. Based on the novel topology, the filter can be readily implemented monolithically and a prototype circuit was fabricated in the 0.18 μm standard complementary-metal-oxide-semiconductor (CMOS) process. It occupied a small area of 0.068 mm2 and consumed 25 μW from a 1.8 V supply. Measurement results show that the cutoff frequency of the LPF could be linearly tuned from 0.05 Hz to 300 Hz and the total-harmonic-distortion (THD) was less than -76 dB for a 2 Hz, 200 mVpp sine input. The input-referred noises were 5.5 μVrms and 6.4 μVrms for the LPF and NF, respectively. A comparison with conventional designs reveals that the proposed design achieved the lowest harmonic distortion and smallest on-chip capacitor. Moreover, its ultra-low cutoff frequency and relatively linear frequency tuning capability make it an attractive solution as an analog front-end for biopotential acquisitions.Vitamin D and calcium have different biological functions, so the need for supplementation, and its safety and efficacy, need to be evaluated for each separately. Vitamin D deficiency is usually the result of low sunlight exposure (e.g., in frail older people, those who are veiled, those with dark-skin living at higher latitudes) and is reversible with calciferol 400-800 IU/day. Calcium supplements produce a 1% increase in bone density in the first year of u

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