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https://www.selleckchem.com/products/ly2606368.html In this work, we developed a facile end-functionalization method using hydroxylated coumarin to initiate the ring-opening polymerization of cyclic esters to synthesize a series of fluorescent biodegradable aliphatic polyesters with tailorable properties. The resulting fluorescent functionalized poly(l-lactide) (PLLA-COU), poly(ε-caprolactone) (PCL-COU) poly(δ-valerolactone) (PVL-COU) and poly(trimethylene carbonate) (PTMC-COU) were investigated to evaluate the dependence of fluorescence on the chemical structure and molecular weight of the materials. The differences in the electron withdrawing ability and the density of ester groups are responsible for the changes in the fluorescence quantum yield. Then, two representative biodegradable materials, namely, PLLA-COU and PCL-COU, were used to prepare fluorescent paclitaxel-loaded microspheres. During in vitro drug release, the release rate of the PCL-COU microspheres is dramatically faster than that of the PLLA-COU microspheres due to the difference in the material nature and their surface morphologies, possibly achieving a tunable degradation and release rate for the drug carriers. Fluorescent functionalized polyester microspheres can retain their fluorescence properties and emit bright blue light for fluorescence tracing during the degradation process. Biological evaluations showed that both fluorescent polyesters are devoid of any significant toxicity and have good biocompatibility. The results demonstrated that the obtained fluorescent polyesters are promising for use in traceable and controlled drug delivery with tunable drug release.Developing efficient methods for the real-time detection of Zn2+ levels in biological systems is highly relevant to improving our understanding of the role of Zn2+ in the progression of Parkinson's disease (PD). In this work, a novel Schiff base based Zn2+ fluorescent probe (ZP) was designed, synthesized and systematically investigat

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