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https://www.selleckchem.com/products/voruciclib.html And several examples of applications were summarized. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.The non-enzymatic interaction of sugar and protein resulting in the formation of advanced glycation end products responsible for cell signaling alterations ultimately lead to the human chronic disorders such as diabetes mellitus, cardiovascular diseases, cancer, etc. Studies suggest that AGEs upon interaction with receptors for advanced glycation end products (RAGE) result in the production of pro-inflammatory molecules and free radicals that exert altered gene expression effect. Till date many studies unveiled the potent role of synthetic and natural agents in inhibiting the glycation reaction at lesser or greater extent. This review focuses on the hazards of glycation reaction and its inhibition by natural antioxidants including polyphenols. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Accumulating evidence demonstrates that miRNAs serve as critical biomarkers in various complex human diseases. Thus, identifying potential miRNA-disease associations have become a hot research topic for providing better understanding of disease pathology, including cell carcinoma, cell proliferation and mevalonate pathway. Recently, based on various biological datasets, more and more computational prediction methods have been designed to uncover disease-related miRNAs for further experimental validation. Due to the fact that different limitations exist in previous computational methods, we proposed the model of Decision Template-based MiRNA-Disease Association prediction (DTMDA) to prioritize potential related miRNAs for diseases of interest. By integrating miRNA functional similarity network, miRNA Gaussian interaction profile kernel similarity network, two disease semantic similarity networks and disease Gaussian interaction profil

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