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In vitro formed fibrils of Aβ1-42 were partially disaggregated in the presence of p-cymene. p-Cymene could act on this AD model via antioxidant and anti-inflammatory properties as well as direct anti-fibril effect. p-cymene can improve AD-related disorders including memory impairment. p-cymene can improve AD-related disorders including memory impairment. Hypertriglyceridemia (HG) is an independent risk factor with more prevalence than hypercholesterolemia and its attributes to cardiovascular disease (CVD) and pancreatitis. Hence, it becomes imperative to search for new triglyceride (TG) lowering agents. (TC) is a well-known Ayurvedic drug and a rich source of protoberberine alkaloids hence can contribute to TG lowering without side effects. https://www.selleckchem.com/products/lw-6.html Hence, to explore the therapeutic efficacy of T. cordifolia and its effects on biochemistry and metabolome in the patients of hyper-triglyceridemia, clinical trials were conducted. Patients (n = 24) with hypertriglyceridemia were randomized into two groups to receive T. cordifolia (TCE) (3.0g/per day) and metformin (850mg/day) for 14days having >300mg/dl triglyceride level and cholesterol in the range of 130-230mg/dl. Lipid profiles of blood samples were analyzed. Urine samples were subjected to HPLC-QTOF-MS to quantify oxidative damage and abnormal metabolic regulation. Intervention with TCE reduced the triglyceride, LDL, and VLDL levels to 380.45 ± 17.44, 133.25 ± 3.18, and 31.85 ± 5.88mg/dL and increased the HDL to 47.50 ± 9.05mg/dL significantly (p < 0.05) in the HG patients after 14days treatment. TCE dosage potently suppressed the inflammatory and oxidative stress marker's i.e. levels of isoprostanes significantly (p < 0.01). Qualitative metabolomics approach i.e. PCA and PLS-DA showed significant alterations (p < 0.05) in the levels of 40 metabolites in the urine samples from different groups. TCE administration depleted the levels of markers of HG i.e. VLDL, TG, and LDL significantly. Metabolomics studies established that the anti-HG activity of TCE was due to its antioxidative potential and modulation of the biopterin, butanoate, amino acid, and vitamin metabolism. India (CTRI) registration no. CTRI- 2016-08-007187. India (CTRI) registration no. CTRI- 2016-08-007187. Cardiovascular autonomic neuropathy (CAN) is one of the most common and serious complications associated with diabetes and is defined as the impairment of the autonomic control of the cardiovascular system, whose prevalence in Indian population has been reported to be > 50%. The risk factors associated with CAN include hyperglycemia, duration of diabetes, hypertension, dyslipidemia, and obesity. This study was conducted to examine the association of CAN with its determinants among diabetics. Socio-demographic characteristics were noted alongwith performance of biochemical analyses of blood samples according to standard hospital pathology laboratory protocols. Clinical assessment of CAN comprised a of 5 indexes, including 3 heart rate variability parameters (resting tachycardia, Qtc interval > 440 msec, exercise intolerance) and 2 blood pressure parameters (orthostatic hypotension, abnormal hand gripping test). The odds of CAN increased with poor glycemic control (FBS ≥ 126mg/dL (OR = 1.17 (1.02-10.68); 2 hr PPBS ≥ 200mg/dL (OR 1.63 (1.26-8.82) and HbA1c ≥ 6.5% (OR = 10.68 (1.54-208.02). Significant difference was also found in relation to duration of diabetes, weight and body mass index of the participants with various grades of CAN. CAN is associated strongly with poor glycemic control. Obesity seems to be involved in the impairments of the cardiac autonomic function and this factor must therefore be taken into account in future studies when interpreting the results. Body mass control and glycemic control could provide an important approach to reducing CAN. CAN is associated strongly with poor glycemic control. Obesity seems to be involved in the impairments of the cardiac autonomic function and this factor must therefore be taken into account in future studies when interpreting the results. Body mass control and glycemic control could provide an important approach to reducing CAN. Studies over the past decades have observed a sharp rise in the prevalence and incidence of type 2 diabetes mellitus (T2DM). A highly sensitive and specific predictive tool for risky populations is essential. This study assessed two significant diabetes mellitus predictive tools for effectiveness and accuracy among people living in fishing communities in Cape Coast, Ghana. In April 2019, we recruited one hundred and thirty-five (135) fishermen from three fishing communities in Cape Coast in the Central Region of Ghana. Each participant underwent a standard metabolic procedure including clinical examination as well as taking of anthropometric variables such as weight, height, waist and hip circumference were also measured. The FINDRISC questionnaire was used to gather data from the respective participants. Serum glucose and lipids were estimated with enzymatic techniques, and metabolic syndrome (MetS) screened with the international diabetes federation (IDF) criteria. Of the 135 participants, 71 (52.6%) -off value of 13.5) and MetS screening tools possess a good predictive capacity for the detection of T2DM. Additionally, FINDRISC can be employed to detect MetS in a high-risk population. Our findings indicate that both FINDRISC (with a suitable cut-off value of 13.5) and MetS screening tools possess a good predictive capacity for the detection of T2DM. Additionally, FINDRISC can be employed to detect MetS in a high-risk population. Diabetes mellitus is a prevalent metabolic disorder that entails numerous complications in various organs. In current era, different types of diseases are being treated by the applications of herbs. The present study is aimed at investigating the anti-inflammatory and antioxidant effects of the hydroethanolic extracts (RFHE) in the streptozotocin (STZ)-induced diabetic rats. At this experimental research, male Wistar rats with the weight of 220 ± 20g, were categorized randomly into five groups of vehicles as control, STZ (60mg kg of body weight, intraperitoneally (i.p.)) and RFHE (50, 100 and 200mg kg , i.p.). In the last stage (end of week 4) of the experiment, after being euthanized, the blood samples of the rats were collected for measuring malondialdehyde (MDA), glutathione (GSH), total antioxidant status (TAS) as well as inflammatory markers like tumor necrosis factor (TNF)-α, interleukin (IL)-6 and C-reactive protein (CRP). Data from this study was revealed that diabetes causes oxidative damage and consequently the serum level of inflammatory markers rises.
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