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https://www.selleckchem.com/products/procyanidin-c1.html The accuracy of the 4 topographic assessments in determining the centre coordinates of the MCL with respect to SL assessment was good no differences were found in the left eyes and although in the right eyes a more temporal and superior position of MCLs was determined (paired t-test, p less then 0.05) the difference was clinically negligible (0.16 ± 0.36 mm horizontally, 0.23 ± 0.48 vertically). Amongst the 4 practitioners one-way Anova for repeated measures showed no differences for any of the 3 manual assessments. Intra-class correlation coefficient was calculated among the 3 readings for each manual procedure and was very good (between 0.75 and 0.98) in 3 practitioners and moderate (between 0.49 and 0.92) in the fourth. CONCLUSIONS The assessment of MCL centration by performing corneal topography over the MCL is an accurate method. Furthermore, inter and intra-practitioner reliability showed by manual procedures appeared very good. PURPOSE To examine the influence of short-term fenestrated scleral lens wear on intraocular pressure (IOP) in healthy eyes. METHODS IOP was measured before, during, and after a brief period (1-2 min) of fenestrated, scleral lens wear, using a rebound tonometer, in fifty, young healthy adults (mean age 23 ± 4 years) with normal corneas. RESULTS Immediately following lens insertion, 48 of the 50 (96 %) of participants displayed an increase in IOP (mean ± SD increase in these participants of 3.8 ± 2.0 mmHg). Immediately following lens removal, 50 % of participants displayed a reduction in IOP, equal to or lower than, the pre-insertion IOP (-1.0 ± 0.8 mmHg lower than baseline). The remaining 50 % of participants displayed an IOP slightly greater than the pre-insertion IOP (1.6 ± 1.0 mmHg greater) after lens removal. CONCLUSIONS Short-term fenestrated scleral lens wear resulted in a small, but statistically significant, increase in IOP in 96 % of young healthy participants ( less then

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