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https://www.selleckchem.com/products/cb-5339.html certain patient populations for this procedure. Limited studies have examined the relationship between axial rotational alignment and functional outcome in mobile-bearing UKA. The aims of this study was to determine the correlation between component axial rotational alignment and functional outcomes, and to recommend a safety range for component rotation for Oxford UKA. A retrospective study of 83 Oxford UKA was performed in 67 patients. Postoperative CT scans and clinical assessments were performed at a mean follow up of 21months. Functional outcomes were measured by the OKS, modified KSS and KFS scores. A moving threshold analysis was performed to evaluate the relationship between different rotational alignment cut-off values and functional outcome scores. The mean femoral and tibial components were positioned with a mean of 4.8° and 7.5° external rotation (ER), respectively. Increasing tibial external rotation was negatively correlated with clinical outcome scores while increasing femoral component rotation did not correlate with clinical outcomes. Better functional scores were observed at mean femoral and tibial rotation angles between 2-6° ER (1.2-6.6°) and 1-8° ER (0.5-8.8°), respectively; with the highest OKS, KSS and FKS observed at 3-4° ER for femoral component, and 4-5° ER for tibial component. Femoral component axial rotation between 2°- 6° ER, and tibial component axial rotation between 1° and 8° ER correlated with significantly better functional scores. Surgeons should be especially aware of the relatively high variability in tibial component rotation and its implications of functional outcomes. Femoral component axial rotation between 2°- 6° ER, and tibial component axial rotation between 1° and 8° ER correlated with significantly better functional scores. Surgeons should be especially aware of the relatively high variability in tibial component rotation and its implications of functional outcomes. To e

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