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https://www.selleckchem.com/products/gsk2578215a.html Vaccination is an effective means to prevent infectious diseases including tick-borne encephalitis (TBE), an emerging Flavivirus infection. There is, however, only limited knowledge about risk of vaccination failure, the disease course and the challenges for work-up and care. Of note, there is evidence that patients with breakthrough disease experience a more severe disease course. We report the case of a previously healthy 49-year-old woman who developed severe myeloradiculitis caused by the TBE virus despite receiving a complete cycle of primary immunization and booster vaccinations within the recommended timeframe. The disease course was characterized by progressive tetraparesis, pain and bladder dysfunction and necessitated intensive care unit admission (ICU) and the escalation of pain management. This case raises awareness for the recognition of breakthrough disease in younger patients and reinforces the need to develop measures to identify patients with insufficient protection.The continuous evolution of the agricultural sector justifies the incorporation and adaptation of the latest technologies. Nowadays, managing crops is possible through Internet-based technologies. Their application allows for the exploitation of information and the development of isolated applications, which, although powerful, create challenges for obtaining scalable predictions throughout the useful life of farms. To address this problem, a data model was defined to improve the management of crop plots in irrigation communities and simultaneously monitor crop needs. Consequently, the objective of this study was to create an open and interoperable platform based on standard interfaces and protocols to enable the integration of heterogeneous sources of information, while ensuring interoperability with other third-party solutions for exchanging and exploiting such information. Standard and open interfaces and protocols form the basis o

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