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https://www.selleckchem.com/products/sodium-cholate.html 83, p<0.001, and 0.55, p=0.010 respectively). Lower HbA1c was independently linked with female concordant dyads (-0.84, p<0.001). This study highlights the importance of female gender concordance on perceptions of interpersonal processes of diabetes care and glycemic control. Strengthening physicians' communication skills with female patients should be taken into consideration. Strengthening physicians' communication skills with female patients should be taken into consideration. South Korea introduced the patent linkage system in 2015 as part of the implementation of free trade agreements with the United States. This study assessed trends in brand-name drug patenting and generic patent challenges in South Korea after the introduction of the system. From 2012-19, we constructed a novel dataset that combines information about listed patents with their corresponding brand-name drugs and patent challenges against these brand-name drugs. We analyzed brand-name drug patenting and generic patent challenges and elucidated factors in timely patent challenges using event history analysis. During the study period, 659 brand-name drugs listed their patents in the K-Orange Book and patent challenges against 95 brand-name drugs were initiated. The number of listed patents and their nominal patent term varied by the characteristics of the brand-name drugs. Patent challenges of generic drugs were marginal in South Korea even though the surge of patent challenges of generics were noticed right after the introduction of the patent linkage system. Patenting and patent challenges are critical factors when introducing generic drugs into the market under the patent linkage system. However, the impact of the patent linkage system on patenting and patent challenges could be varied by the specific form of the patent linkage system and the contexts of pharmaceutical markets. Patenting and patent challenges are critical factors when in

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