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https://www.selleckchem.com/products/tas-102.html BACKGROUND Donor-recipient oversizing based on predicted total lung capacity (pTLC) is associated with a reduced risk of primary graft dysfunction (PGD) following lung transplant but the effect varies with the recipient's diagnosis. Chest x-ray (CXR) measurements to estimate actual total lung capacity (TLC) could account for disease-related lung volume changes, but their role in size matching is unknown. METHODS We reviewed adult double lung transplant recipients 2007 - 2016 and measured apex-to-costophrenic-angle distance (=lung height) on pretransplant donor and recipient CXRs [oversized donor-recipient ratio > 1; undersized ≤ 1]. We tested the relationship between recipient lung height to actual TLC; between lung height ratio and donor/recipient characteristics; and between both lung height ratio or pTLC ratio and grade 3 PGD with logistic regression. RESULTS 206 patients were included and 32 (16%) developed grade 3 PGD at 48 or 72 hours. Recipient lung height was related to TLC (r 0.7297). Pulmonary diagnosis, donor BMI and recipient BMI were the major determinants of lung height ratio (AUC 0.9036). Lung height ratio oversizing was associated with increased risk of grade 3 PGD (OR 2.51 [95% CI 1.17 - 5.47]; p=0.0182) in this cohort, while pTLC ratio oversizing was not. CONCLUSIONS CXR lung height estimates actual TLC and reflects pulmonary diagnosis and body composition. Oversizing via CXR lung height ratio increased PGD risk moreso than pTLC-based oversizing in our cohort.Long-term safety of living kidney donation, especially for young donors, has become a real matter of concern in the transplant community and may contribute to creating resistance to LKD. In this context, the criteria that govern living donor donations must live up to very demanding standards as well as adjust to this novel reality. In a first part, we review the existing guidelines published after 2010 and critically examine their recommendatio

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