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https://www.selleckchem.com/products/rmc-4630.html Discrete junctional cellular aggregates ("nests"), partially staining with melanocytic markers, are described in lichenoid tissue reaction, mainly from chronically sun-exposed skin. The concomitant epidermal flattening and papillary dermal fibrosis with melanophages, may raise the differential diagnosis with a regressing melanoma. We describe three cases of interface dermatitis of the head/neck area with clinicopathological features of melanotic discoid lupus erythematosus/lichen planus pigmentosus. These cases showed junctional aggregates, some composed of inflammatory cells and colloid bodies ("pseudomelanocytic nest"), and some others composed of S100- but MART-1+, MITF+, and SOX-10+ cells ("true melanocytic nests"); negativity of the melanocytic component for PRAME was a clue to benignity. True junctional melanocytic nesting may be induced by lichenoid dermatoses on chronically sun-damaged skin. The presence of colloid bodies and the double negativity to S100 (within the nests) and PRAME (within both the nests and the single melanocytes) may warrant clinicopathological correlation in order to avoid misdiagnosis. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.There is considerable interest in incorporating fluorine in agrochemicals and pharmaceuticals to improve their biological properties. Whilst a number of methods have been reported for installing CH 2 F and CHF 2 groups, they are mainly limited to radical reactions which are invariably racemic. Herein, we report the divergent, stereospecific reaction of fluoroiodomethyllithium with boronic esters which give α-fluoro-boronic esters. These unique intermediates can be readily transformed into the corresponding mono- or difluoromethylated compounds, via proto- or fluorodeboronation, respectively. The use of the highly unstable fluoroiodomethyllithium was key to allowing rapid 1,2-migration

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