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https://www.selleckchem.com/products/th1760.html Epididymal protease inhibitor (EPPIN) is differentially expressed in the reproductive tissues (such as testicles, outlet tubes, epididymis, vas deferens, and seminal vesicles). Its critical role in sperm function and male reproduction has shed light on EPPIN as a candidate target for male contraceptive vaccines. In this study, we endeavored to further reveal the mechanism through which EPPIN exerts its function. We created a mouse model of reduced Eppin expression by microinjecting small interfering RNA targeting Eppin expression into seminiferous tubules of mice. This mouse model was then used to explore the effects of low Eppin expression on sperm function, which was assessed by Computer Assisted Semen Analysis and patch clamp recording of T-type Ca2+ current in spermatogenic cells. We found that the sperm motility significantly declined when Eppin was downregulated. Further investigation demonstrated that Eppin downregulation significantly affected T-type Ca2+ currents and messenger RNA expression of three subtypes of T-type Ca2+ channels in spermatogenic cells. These findings indicate that low Eppin gene expression induces decreased T-type Ca2+ currents and mRNA expression, which in turn results in the reduced sperm motility.The purpose of this systematic review was to evaluate the potential benefits of antioxidant enrichment of semen extenders. These substances are used to combat oxidative stress during processing and conservation of rooster semen. A literature search was performed in June 2020 using the keywords rooster AND (semen OR spermatozoa OR sperm OR ejaculate OR ejaculation). This report followed the PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) guidelines. The PICO (population intervention comparison outcome) question was defined to compare roosters (Population) which had added antioxidants in the semen (Intervention) compared to the no-antioxidant group (Control); the outco

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