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https://www.selleckchem.com/products/catechin-hydrate.html Further association analyses showed that the cortical alterations were significantly correlated with verbal memory and WMH burden in SACS. These results suggest that SACS patients present a left-dominated damage tendency, especially in the Perisylvian cortices that span across several large-scale systems of somatosensory/motor and language. Our findings also provide cortical anatomy evidence for cognitive impairment in SACS, suggesting a neuroanatomical predisposition to dementia and cerebrovascular events.With a greatly changed environment, sleep problem becomes a common phenomenon among college freshmen. However, this type of acute insomnia usually recovers after adapting to the circumstances, which can be defined as adaptive sleep problem (ASP). Few studies deal with this type of sleep problems. In this study, 991 first-year college freshmen were recruited on different days of the first semester to investigate their sleep status. We found that the sleep problem of college freshmen at the beginning of the semester was the most severe, compared with the other two-thirds of semester. Next, behavioral and resting-state functional magnetic imaging (rs-fMRI) data from 30 freshmen with ASP and 28 matched healthy controls (HC) were used to explore the neural basis of acute insomnia. Results showed that ASP group performed worse on many behavioral indices, such as fatigue, depression, and trait anxiety. Interestingly, students with ASP also showed significantly more negative functional connectivity between the anterior default mode network (aDMN) and the dorsal attentional network (DAN). Furthermore, a significant negative correlation was observed between Insomnia Severity Index (ISI) score and aDMN-DAN functional connectivity in the HC group, which was not observed in the case of ASP. In conclusion, the study explored the neural biomarker of adaptive sleep problem (ASP) in freshmen, and found its potentiating ant

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