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https://www.selleckchem.com/products/tak-981.html Membrane phospholipase D (PLD) is associated with numerous neuronal functions, such as axonal growth, synaptogenesis, formation of secretory vesicles, neurodegeneration, and apoptosis. PLD acts mainly on phosphatidylcholine, from which phosphatidic acid (PA) and choline are formed. In turn, PA is a key element of the PLD-dependent secondary messenger system. Changes in PLD activity are associated with the mechanism of action of olanzapine, an atypical antipsychotic. The aim of the present study was to assess the effect of short-term administration of the first-generation antipsychotic drugs haloperidol, chlorpromazine, and fluphenazine on membrane PLD activity in the rat brain. Animals were sacrificed for a time equal to the half-life of the antipsychotic drug in the brain, then the membranes in which PLD activity was determined were isolated from the tissue. The results indicate that only haloperidol in a higher dose increases the activity of phospholipase D. Such a mechanism of action of haloperidol has not been described previously. Induction of PLD activity by haloperidol may be related to its mechanism of cytotoxicity. The finding could justify the use of PLD inhibitors as protective drugs against the cytotoxicity of first-generation antipsychotic drugs like haloperidol.Molybdenum and tungsten carbides are perspective catalytic systems. Their activity in many reactions is comparable to the activity of platinum group metals. The development of the synthesis method for of highly dispersed binary molybdenum and tungsten carbides is an important task. Dispersions of molybdenum-tungsten blue were used as a precursor for synthesis of binary molybdenum and tungsten carbides. The synthesis of carbides was carried out by thermal decomposition of molybdenum-tungsten blue xerogels in an inert atmosphere. The binary carbides were characterized by XRD, TGA, SEM and nitrogen adsorption. The influence of the molar ratio reduci

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