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https://www.selleckchem.com/products/cay10603.html Fewer aged than adult ALDH+CD44+ keratinocyte SCs exhibited p53 expression and activity and Nutlin-3 (a p53 activator) returned p53 activity as well as asymmetric SC self-renewal divisions to adult levels. Nutlin-3 increased Notch signaling (NICD, Hes1) and DAPT inhibition of Notch activation prevented Nutlin-3 (p53)-induced asymmetric SC self-renewal divisions in aged keratinocytes. These studies indicate a role for p53 in the decreased asymmetric SC divisions with age and suggest that in aged keratinocytes, Notch is required for p53-induced asymmetric SC divisions.Separating acetylene from carbon dioxide is important but highly challenging owing to their similar physical properties and molecular dimensions. Herein, we report highly efficient electrostatically driven CO2 /C2 H2 separation in an ultramicroporous cadmium nitroprusside (Cd-NP) with compact pore space and complementary electrostatic potential well fitting for CO2 , thus enabling molecular quadrupole moment recognition of CO2 over C2 H2 . This material shows a high CO2 /C2 H2 uptake ratio of 6.0 as well as remarkable CO2 /C2 H2 selectivity of 85 under ambient conditions with modest CO2 heat of adsorption. Neutron powder diffraction experiments and molecular simulations revealed that the electrostatic potential compatibility between pore structure and CO2 allows it to be trapped in a head-on orientation towards the Cd center, whereas the diffusion of C2 H2 is electrostatically forbidden. Dynamic breakthrough experiments have validated the separation performance of this compound for CO2 /C2 H2 separation. In this retrospective study, we examined the CA17 tissue expression and analyzed its clinical significance in cholangiocarcinoma (CCA). Immunohistochemistry was performed to assess CA17 expression on tissue microarrays in a training cohort enrolling 120 CCA patients and a validation cohort comprising 60 CCA patients. Image pro plus was applied to score t

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