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https://www.selleckchem.com/products/bos172722.html Afferent somatosensory information plays a crucial role in modulating efferent motor output. A better understanding of this sensorimotor interplay may inform the design of neurorehabilitation interfaces. Current neurotechnological approaches that address motor restoration after trauma or stroke combine motor imagery (MI) and contingent somatosensory feedback, e.g., via peripheral stimulation, to induce corticospinal reorganization. These interventions may, however, change the motor output already at the spinal level dependent on alterations of the afferent input. Neuromuscular electrical stimulation (NMES) was combined with measurements of wrist deflection using a kinematic glove during either MI or rest. We investigated 360 NMES bursts to the right forearm of 12 healthy subjects at two frequencies (30 and 100 Hz) in random order. For each frequency, stimulation was assessed at nine intensities. Measuring the induced wrist deflection across different intensities allowed us to estimate the input-output curve (IOC) of the spinal motor output. MI decreased the slope of the IOC independent of the stimulation frequency. NMES with 100 Hz vs. 30 Hz decreased the threshold of the IOC. Human-machine interfaces for neurorehabilitation that combine MI and NMES need to consider bidirectional communication and may utilize the gain modulation of spinal circuitries by applying low-intensity, high-frequency stimulation.Synthetic biology holds promise to revolutionize the life sciences and biomedicine via expansion of macromolecular diversity outside the natural chemical space. Use of non-canonical amino acids (ncAAs) via codon reassignment has found diverse applications in protein structure and interaction analysis, introduction of post-translational modifications, production of constrained peptides, antibody-drug conjugates, and novel enzymes. However, simultaneously encoding multiple ncAAs in vivo requires complex engineering an

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