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https://www.selleckchem.com/products/OSI-906.html In the fight against the COVID-19 pandemic, understanding how the public responds to various initiatives is an important step in assessing current and future policy implementations. In this paper, we analyzed Twitter tweets using topic modeling to uncover the issues surrounding people's discussion of the disease. Our focus was on temporal differences in topics, prior and after the declaration of COVID-19 as a pandemic. Nine topics were identified in our analysis, each of which showed distinct levels of discussion over time. Our results suggest that as the pandemic progresses, the concerns of the public vary as new developments come to light.Systemic delivery of therapeutics for treatment of lung diseases has several limitations including poor organ distribution of delivered payload with relatively low accumulation of active substances in the lungs and severe adverse side effects. In contrast, nanocarrier based therapeutics provide a broad range of opportunities due to their ability to encapsulate substances with different aqueous solubility, transport distinct types of cargo, target therapeutics specifically to the deceased organ, cell, or cellular organelle limiting adverse side effects and increasing the efficacy of therapy. Moreover, many nanotherapeutics can be delivered by inhalation locally to the lungs avoiding systemic circulation. In addition, nanoscale based delivery systems can be multifunctional, simultaneously carrying out several tasks including diagnostics, treatment and suppression of cellular resistance to the treatment. Nanoscale delivery systems improve the clinical efficacy of conventional therapeutics allowing new approaches for the treatment of respiratory diseases which are difficult to treat or possess intrinsic or acquired resistance to treatment. The present review summarizes recent advances in the development of nanocarrier based therapeutics for local and targeted delivery of drugs, nuclei

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