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https://www.selleckchem.com/products/pf-2545920.html This study aim at investigating the function of microRNA (miR)-34b-5p in breast cancer prognosis and development. qRT-PCR was used for miR-34b-5p expression examination in breast cancer samples. CCK8, immunohistochemistry, scratch wound healing, transwell assays were performed for cell experiments. Subcutaneously implanted tumor model was carried out for animal experiment. Western blot was conducted for protein expression detection. Bioinformatics analysis was performed for exploring the underlying mechanism. MiR-34b-5p expression was down-regulated in breast cancer samples and cells, and miR-34d-5p could inhibit cell viability, migration and invasion also delay tumor growth in vivo. Low miR-34b-5p expression showed a bad prognosis of breast cancer patients. MiR-34b-5p functioned as a tumor suppressor by targeting ARHGAP1, and ARHGAP1 knockdown could reverse the effect of miR-34b-5p inhibitor on breast cancer cells. MiR-34b-5p exerts an anti-tumorigenesis role in breast cancer cells by targeting ARHGAP1, which is profitable for the breast cancer diagnosis and molecular treatment. AJTR Copyright © 2020.Osteoarthritis (OA) is the most common cause of disability in worldwide population, which is characterized by cartilage breakdown, synovial fibrosis, osteophyte formation and pain. Synovial inflammation is usually found in both early and late stages in most of the OA patients. Macrophages, the major component of the mononuclear phagocyte system, play a critical role in OA pathogenesis through the induction of inflammatory mediators, growth factors and proteinases. So, drugs that can target macrophages and macrophage-associated inflammatory pathways at an appropriate stage may help to inhibit or slow down the progression of OA. However, despite an emerging role of synovial macrophages in OA pathogenesis, little is known about the biology of synovial tissue macrophages, and attempts to target macrophages therapeuticall

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