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https://www.selleckchem.com/products/protokylol-hydrochloride.html The phytochemical study of the CH2Cl2- MeOH (11, v/v) extract of the stem bark of Carapa procera DC (Meliaceae) led to the isolation and characterisation of a new natural limonoid 7β-obacunol (6), along with seven known compounds. Their structures were elucidated by spectroscopic means, including 1 D and 2 D NMR, HRESI-MS and by comparison with published data. The cytotoxicity of compounds 1-6 was assessed in vitro by the WST-1 assay on human lung adenocarcinoma A549 and Raw 264.7 mouse macrophage cell lines. Results suggested that obacunone (3) exhibited the most potent cytotoxic effect against A549 and Raw 264.7 cells with respective IC50 values of 25.24 µM and 29.14 µM, while the new natural limonoid 7β-obacunol (6) exhibited 32.75 µM and 39.19 µM, respectively on both cell lines. Therefore, limonoid derivatives might be promising sources of natural bioactive metabolites against cancer.This study examined the feasibility of using crowdsourcing to recruit men who self-report sexual interest in children or sexually problematic behavior involving children. Crowdsourcing refers to the use of the internet to reach a large number of people to complete a specific task. A nonrepresentative sample of men (N = 997) participated in a brief self-report survey examining age of attraction, sexual interest in children, proclivity toward sexual offenses involving children, and history of sexual offending. Almost a quarter of the sample (23.1%) indicated some degree of sexual interest in children, propensity to sexually offend against children, and/or actual offending behavior. We present our data broken down by type of interest or behavior and examine the frequency of these outcomes. Findings are likely to be of value to those considering the viability of crowdsourcing to overcome the limitations or challenges of face-to-face research on stigmatizing interests and behaviors. Findings also contribute to estimating

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