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https://www.selleckchem.com/products/PLX-4032.html INTRODUCTION The prognosis of pancreatic ductal adenocarcinoma has been associated with several factors. The aim of the present study was to correlate tumor-related factors and pathological findings with disease-free survival (DFS) and overall survival (OS) in patients undergoing pancreaticoduodenectomy. MATERIAL AND METHODS From a prospectively maintained database, we reviewed 89 pancreatic ductal adenocarcinomas in patients who underwent pancreaticoduodenectomy from 2010 to 2014. The impact of histopathologic or tumor-related data, including a lymph node ratio greater than 15% (LNR15), on survival was analyzed. RESULTS Univariate analysis of DFS and OS showed that vascular resection, pT, pN, LNR15, microvascular, lymphatic, and perineural invasion, and R1 resection influenced survival. Only LNR15, perineural invasion and R1 resection were independent predictors for both DFS (HR 6.39, p = 0.011; HR 8.53, p = 0.003; HR 9.68, p = 0.002, respectively) and OS (HR 4.21, p = 0.039; HR 5.41, p = 0.020; HR 4.41, p = 0.036, respectively). CONCLUSIONS This study demonstrates that LNR15, perineural invasion and R1 resection are independently associated with DFS and OS.Office-based gynecologic surgery (OBGS) has become an integral part of modern practice. The technological achievements of the past few decades have dramatically improved our ability to diagnose and treat a variety of common issues that affect fertility and menstruation. Procedures that once required the complex milieu of a hospital or outpatient setting-diagnostic hysteroscopy, endometrial ablation, hysteroscopic polypectomy, and myomectomy-are now well within the reach of motivated and well-trained practitioners. The recent changes in physician reimbursement and the ongoing need to contain healthcare spending have motivated many gynecologists to offer an array of office-based procedures. But, the transition from a hospital-based technique to one that can safely

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