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https://www.selleckchem.com/products/itd-1.html This study reports the accelerometer-based physical activity (PA) and sedentary behavior (SB) before and during the COVID-19 pandemic in hypertensive older adults. Thirty-five hypertensive older adults were included in this observational study. Accelerometer-based PA and SB measures were assessed before (January to March 2020) and during (June 2020) the COVID-19 pandemic. Linear mixed models were used to assess within-group changes in PA and SB measures, adjusted by accelerometer wear time. Before COVID-19 pandemic participants presented 5809steps/day (SE=366), 303.1min/day (SE=11.9) of light PA, 15.5min/day (SE=2.2) of moderate-vigorous PA, and 653.0min/day (SE=12.6) of SB. During COVID-19 pandemic there was a decrease in steps/day (β=-886steps/day, SE=361, p=0.018), in moderate-vigorous PA (β=-2.8min/day, SE=2.4, p=0.018), and a trend in light PA (β=-26.6min/day, SE=13.4, p=0.053). In addition, SB increased during the COVID-19 pandemic (β=29.6min/day, SE=13.4, p=0.032). The magnitude of changes was greater on the weekend, mainly for steps/day (β=-1739steps/day, SE=424, p<0.001) and the SB pattern (more time spent in bouts of ≥10 and 30min, less breaks/day and breaks/h). The COVID-19 pandemic may elicit unhealthy changes in movement behavior in hypertensive older adults. Lower PA, higher and more prolonged SB on the weekend are the main features of the behavioral changes. The COVID-19 pandemic may elicit unhealthy changes in movement behavior in hypertensive older adults. Lower PA, higher and more prolonged SB on the weekend are the main features of the behavioral changes.Circular RNAs (circRNAs) are a class of non-coding RNAs with a special covalently closed circular structure, which is formed by precursor mRNA (pre-mRNA) through "back-splicing". CircRNAs are more stable than linear RNAs because they are resistant to exoribonucleases. Viral infections often cause abnormal expression of circRNAs, which could serve as

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