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https://www.selleckchem.com/products/pf-06424439.html 002, 0.004 less then 0.001, less then 0.001, and 0.048, respectively). Rim enhancement was more prevalent, thicker, and exhibited higher continuity in PFTC than in EOC (p=0.002, less then 0.001, and 0.002, respectively). CONCLUSIONS Rim enhancement is a useful feature in distinguishing PFTC from EOC, particularly when continuous or seen in combination with a sausage-like shape, hydrosalpinx or intrauterine fluid accumulation. When the tumour is associated with other MRI signs, for example, (i) hydrosalpinx with mural papillary nodules or sausage-like shape with mild-to-moderate enhancement of solid components, (ii) hydrosalpinx, or (iii) intrauterine fluid accumulation, the diagnosis of PFTC should be considered. OBJECTIVES Emerging evidence supports sequential therapy with anabolic followed by antiresorptive in patients at high-risk of fragility fractures. This study assessed the cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) [(ABL/ALN)] compared to ALN monotherapy and to sequential treatment starting with antiresorptive therapy (ALN/ABL/ALN). METHODS A previously validated Markov microsimulation model was used to estimate the cost-effectiveness of sequential ABL/ALN compared to ALN monotherapy and to sequential ALN/ABL/ALN from a lifetime US payer perspective. In line with practice guidelines, patients were assumed to receive ABL for 18 months followed by 5 years of ALN, or ALN monotherapy for 5 years, or a sequence of ALN for 2 years followed by 18 months of ABL and then by 3 years ALN. Evaluation was conducted for patients aged 50-80 years old with a BMD T-score ≤-3.5 and without a history of prior fracture, or with a T-score between -2.5 and -3.5 and a history of ≥ 1 osteoporotic fracture. RESULTS Sequential ABL/ALN was cost-effective (threshold of US$150,000 per QALY) vs generic ALN monotherapy in women ≥60 years with a BMD T-score ≤-3.5 and in women with B

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