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https://www.selleckchem.com/products/gsk1120212-jtp-74057.html In addition, this device shows excellent durability and flexibility with multiple optional outputs, demonstrating the potential as a transparent energy supply in planar electronics.Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain cancer, for which effective therapies are urgently needed. Chimeric antigen receptor (CAR)-based immunotherapy represents a promising therapeutic approach, but it is often impeded by highly immunosuppressive tumor microenvironments (TME). Here, in an immunocompetent, orthotopic GBM mouse model, we show that CAR-T cells targeting tumor-specific epidermal growth factor receptor variant III (EGFRvIII) alone fail to control fully established tumors but, when combined with a single, locally delivered dose of IL-12, achieve durable anti-tumor responses. IL-12 not only boosts cytotoxicity of CAR-T cells, but also reshapes the TME, driving increased infiltration of proinflammatory CD4+ T cells, decreased numbers of regulatory T cells (Treg), and activation of the myeloid compartment. Importantly, the immunotherapy-enabling benefits of IL-12 are achieved with minimal systemic effects. Our findings thus show that local delivery of IL-12 may be an effective adjuvant for CAR-T cell therapy for GBM. This case report details the surgical treatment of an RA patient who presented with concomitant AAI and subaxial spondylotic stenosis and was subsequently treated via a C1-2 screw-rod construct, semispinalis cervicis sparing C3 laminectomy, and C4-C7 laminoplasty. Our case report is the first to describe a surgical approach for treatment of concomitant AAI and subaxial spondylotic stenosis in a patient with RA. A 66-year-old male with a history of rheumatoid arthritis and atlantoaxial instability presented to an outpatient spine clinic with complaints of neck pain and worsening gait imbalance. A flexion-extension MRI revealed compression of the posterior aspec

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