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https://www.selleckchem.com/ Induction of labour (IOL) is an increasingly common obstetric intervention globally. There is a choice of mechanical or pharmacological methods for induction of labour when the cervix is unfavorable. Which approach is both effective and safe however is not clear due to how trials are designed and reported. A tradeoff between the common primary outcomes of vaginal birth or time to delivery and rare safety outcomes mean trials are underpowered to determine both. There is also a lack of reporting of the indications for the operative births (prolonged labour or fetal compromise) and their relationship to each IOL method. We recommend that future trials should be large enough to adequately assess both effectiveness and safety outcomes, and that the indications for operative birth are also reported. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.BACKGROUND The mesial surface of the first permanent molar is the most caries susceptible proximal surface of the permanent dentition in children under the age of 12. AIM The aim of this study was to determine the association between caries progression on the mesial surface of the first permanent molar (T6M) and caries on the distal surface of the primary second molar (t5D) and the occlusal surface of the first permanent molar (T6O). DESIGN Children (between 5-13 years old) (N=565) that had participated in a 4-year longitudinal study caries study that at baseline had at least one T6 fully erupted with a t5 in proximal contact, with no restoration or sealant on T6O and t5D, and adequate bite-wing radiographs were eligible. Clinical data using the International Caries Detection and Assessment System (ICDAS) and radiographs were used to determine the caries status of T6M, T6O and t5D. RESULTS Baseline caries presence on t5D and T6O were highly significantly associated with follow-up caries presence on T6M (p less then 0.001). The ad

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