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https://www.selleckchem.com/products/sr-18292.html 7 ± 7.2, DIM 0.9 ± 0.7, P = 0.15). LQTS patients with a QTc ≥ 480 ms (n=120) had a significantly higher QTc-PRS (89.3 ± 6.7) than patients with a QTc less then 480 ms (n=303, 87.6 ± 7.4, DIM 1.7 ± 0.8, P less then 0.05). There was no difference in QTc-PRS or QTc between genotypes. Conclusions - The QTc-PRS explained less then 2% of the QTc variability in our LQT1-3 cohort, contributing 5 times less to their QTc value than in the general population. This prototype QTc-PRS does not distinguish/predict the clinical outcomes of individuals with LQTS.In the past decade, naturally occurring phytoconstituents have emerged as potential therapeutic agents and alternative to synthetic drugs. However, efficient delivery of hydrophobic phytoconstituents into the body with desired therapeutic efficacy is a key challenge for the pharmaceutical industries due to their insolubility in water and low oral bioavailability. Nanosuspension formulations have shown promises to improve the delivery of the hydrophobic molecules with simultaneously avoiding the drawbacks like carrier toxicity and scale-up issues of other nanotechnology-based drug delivery systems. In this study, we have used morin hydrate (MH), a flavonol, and developed MH nanosuspension formulation (MHNS) to improve its poor physiochemical properties and low oral bioavailability. Different stabilizers with varying concentrations were investigated for preparing nanosuspension. MHNS was characterized by DLS, TEM, FTIR, DSC, powder XRD and was evaluated for its solubility, dissolution, partition coefficient, in-vitro anticancer activity and pharmacokinetics in rats. The optimized nanosuspension formulation, with a size of less then 100 nm, is capable of increasing aqueous solubility, dissolution rate, and oral bioavailability of MH. Moreover, the therapeutic efficacy, in terms of cytotoxicity to human lung cancer cells, of MH was also increased after formulating into nanosuspe

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