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https://www.selleckchem.com/GSK-3.html Similarity between memories is a primary cause of interference and forgetting. Exaggerating subtle differences between memories is therefore a potential mechanism for reducing interference. Here, we report a human fMRI study (n = 29, 19 female) that tested whether behavioral and neural expressions of memories are adaptively distorted to reduce interference. Participants learned and repeatedly retrieved object images, some of which were identical except for subtle color differences. Behavioral measures of color memory revealed exaggeration of differences between similar objects. Importantly, greater memory exaggeration was associated with lower memory interference. fMRI pattern analyses revealed that color information in parietal cortex was stronger during memory recall when color information was critical for discriminating competing memories. Moreover, greater representational distance between competing memories in parietal cortex predicted greater color memory exaggeration and lower memory interference. Together, these findings reveal that competition between memories induces adaptive, feature-specific distortions in parietal representations and corresponding behavioral expressions.SIGNIFICANCE STATEMENT Similarity between memories is a primary cause of interference and forgetting. Here, we show that, when remembering highly similar objects, subtle differences in the features of these objects are exaggerated in memory to reduce interference. These memory distortions are reflected in, and predicted by, overlap of activity patterns in lateral parietal cortex. These findings provide unique insight into how memory interference is resolved and specifically implicate lateral parietal cortex in representing feature-specific memory distortions.As Cancer Discovery turns 10, we reflect on the journal's success and look ahead to the future.Chimeric antigen receptor T-cell treatments and bispecific T-cell engager therapies are showing evi

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