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https://www.selleckchem.com/products/mz-1.html The five grade group system has been validated for men treated with radical prostatectomy. However, the prognostic value for men treated with radiation therapy is uncertain, with prior studies utilising old techniques and doses. We aimed to validate the International Society of Urological Pathology(ISUP) groupings for men treated with contemporary radiation therapy. Men with localised prostate cancer treated with image-guided, dose-escalated (≥78Gy) external beam radiation were identified across four institutions. Primary outcome was time to biochemical failure. Harrell's C index assessed performance of the ISUP system against other grading stratifications. 2205 men were included, withmedian follow-up of 5.6years. Seven-year actuarial rates of biochemical failure for grade groups 1-5 were 9.3%, 10.4%, 13.2%, 12.4% and 23.4%. On multivariate analysis, hazard ratios for biochemical failure were1.19, 1.00, 1.10, 1.05 and 2.10 for grade groups 1-5, relative to 2. P values were only significant for grade grooutcomes. Further work is requiredto validate optimal groupings for modern radiation therapy and investigate the contrasting prognostic capability of grade groups in surgical and radiation therapy patients. Assess upfront Stereotactic radiosurgery (SRS) effectiveness for small cell lung cancer (SCLC) brain metastases (BM). Where possible, a comparison with whole-brain radiotherapy (WBRT) was performed. Following PRISMA and MOOSE guidelines, eligible studies were identified on Medline, Embase, Cochrane Library, and proceedings of annual meetings between inception and July 01, 2020. Nine observational studies with 1638 patients were included. The median overall survival (OS) was 8.3months (95% CI 7.1-9.5months, I2=0%). OS rate at 12months was 39% (95% CI 31-44%, I2=0%). The relative risk between SRS and WBRT for the OS at 12months was 1.33 (95% CI 1.13-1.51, P=0.0001). The projected OS for 6, 12, 18- and 24-months comparing

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