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https://www.selleckchem.com/products/nibr-ltsi.html 115° in GL group, P = .002). Reoperation was required in 6 shoulders (10-year cumulative incidence of 3 [5%] in M group vs. 3 [8%] in GL group) for a total of 16 complications (10-year cumulative incidence of 8 [14%] in M group vs. 8 [20%] in GL group). Notching rates were significantly higher in the M group (77% in M group vs. 47% in GL group, P = .013); differences in severe notching (grade 3 or 4) were clinically relevant but did not reach statistical significance (23% in M group vs. 9% in GL group, P = .22). CONCLUSION Primary RTSA using these first 2 prosthesis designs was associated with good outcomes and low reoperation (5%-8%) and complication (14%-20%) rates at 10 years. The M group had higher rates of notching. These results may provide a benchmark for comparison with newer implants, especially considering that these results include the early RTSA implantation learning curve. Established rheumatoid arthritis (RA) is a term used to distinguish patients with longer disease duration versus early RA or undifferentiated arthritis that may progress to RA. Although, there is no uniform definition for early disease, a cut-off of 2 years is used in most clinical trials and observational studies. In the evaluation of established RA, clinicians should incorporate a comprehensive set of measures addressing (1) disease activity, especially inflammation that may benefit of intensification of therapy, (2) health status, (3) comorbidities, and (4) damage. Ideally, measures should include the patient and physician perspectives and be feasible, reliable, valid and sensitive to change. Traditionally, measures have been incorporated in clinical research, but it would be worthwhile to integrate them into routine care. Data collection systems adapted to rheumatologists needs, could advance care for individual patients and facilitate large observational studies to evaluate interventions for the whole spectrum of RA. Microbial c

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