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https://www.selleckchem.com/products/bi-2493.html The preferences were transitive primarily in relation to edible rather than nonedible goods. © 2020 Published by Elsevier Ltd.Long-term diabetic complications are exacerbated by post-prandial hyperglycemia which could be ameliorated by α-glucosidase inhibitor including oxyresveratrol. Puag-Haad is an aqueous extract from Artocarpus lakoocha Roxb. containing ~65% oxyresveratrol. Oxyresveratrol is an inhibitor of isolated yeast α-glucosidase enzyme but has not been tested on intact gut enterocytes where the enzyme is membrane-bound. Accordingly, differentiated Caco-2 cells that contain the native enzyme were used to test maltose hydrolysis in the present study. The results demonstrated that purified yeast α-glucosidase was non-competitively inhibited by oxyresveratrol (Ki 54.4 ± 0.7 μg/mL) and Puag-Haad (2.7 ± 0.1 μg/mL) compared to 153.8 ± 4.3 μg/mL acarbose, an anti-diabetic drug. In differentiated Caco-2 cells, both oxyresveratrol and Puag-Haad inhibited maltose hydrolysis with lesser potency compared to acarbose. Thus, although weaker than acarbose, oxyresveratrol and Puag-Haad do not inhibit pancreatic amylase which might be a therapeutic asset in preventing fermentation of unabsorbed carbohydrate causes abdominal bloating, flatulence, or diarrhea. Oxyresveratrol and Puag-Haad may help control postprandial hyperglycemia with low risk of gastrointestinal side effects. © 2020 Published by Elsevier Ltd.The effect of particle size on the combustion and explosion properties of grain dust is investigated by Hartmann tube, cone calorimeter (CC), and thermogravimetry (TG), it aims to provide fundamental experimental data of grain dust for an in-depth study on its potential risk. The fine-grain dust facilitates the decrease in the minimum ignition temperature (MIT) of dust layer and dust cloud, as well as the obvious increases in the maximum explosion pressure P max (climbs from 0.36 to 0.49 MPa) and pressure rising rate d

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